In Situ Expression of Heat-Shock Proteins and 3-Nitrotyrosine in Brains of Young Rats Exposed to a WiFi Signal In Utero and In Early Life. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Radiation Research Année : 2013

In Situ Expression of Heat-Shock Proteins and 3-Nitrotyrosine in Brains of Young Rats Exposed to a WiFi Signal In Utero and In Early Life.

Résumé

The bioeffects of exposure to Wireless High-Fidelity (WiFi) signals on the developing nervous systems of young rodents was investigated by assessing the in vivo and in situ expression levels of three stress markers: 3-Nitrotyrosine (3-NT), an oxidative stress marker and two heat-shock proteins (Hsp25 and Hsp70). These biomarkers were measured in the brains of young rats exposed to a 2450 MHz WiFi signal by immunohistochemistry. Pregnant rats were first exposed or sham exposed to WiFi from day 6 to day 21 of gestation. In addition three newborns per litter were further exposed up to 5 weeks old. Daily 2-h exposures were performed blind in a reverberation chamber and whole-body specific absorption rate levels were 0, 0.08, 0.4 and 4 W/kg. 3-NT and stress protein expression was assayed in different areas of the hippocampus and cortex. No significant difference was observed among exposed and sham-exposed groups. These results suggest that repeated exposure to WiFi during gestation and early life has no deleterious effects on the brains of young rats.

Domaines

Toxicologie
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Dates et versions

hal-00835384 , version 1 (18-06-2013)

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Citer

Saliha Aït-Aïssa, Florence Poulletier de Gannes, Murielle Taxile, Bernard Billaudel, Annabelle Hurtier, et al.. In Situ Expression of Heat-Shock Proteins and 3-Nitrotyrosine in Brains of Young Rats Exposed to a WiFi Signal In Utero and In Early Life.. Radiation Research, 2013, 179 (6), pp.707-16. ⟨10.1667/RR2995.1⟩. ⟨hal-00835384⟩
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