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Article Dans Une Revue Carbohydrate Research Année : 2012

Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors

Résumé

Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase

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Chimie

Dates et versions

hal-00834946 , version 1 (17-06-2013)

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H.Q. Li, Y.M. Zhang, S. Favre, P. Vogel, M. Sollogoub, et al.. Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors. Carbohydrate Research, 2012, 356, pp.110-114. ⟨10.1016/j.carres.2011.10.039⟩. ⟨hal-00834946⟩
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