Extra-intestinal malignancies in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (III). - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Crohn's and Colitis Année : 2013

Extra-intestinal malignancies in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (III).

Fernando Magro
  • Fonction : Auteur
Xavier Aldeger
  • Fonction : Auteur
Antonia Costa
  • Fonction : Auteur
Peter D Higgins
  • Fonction : Auteur
Joel C Joyce
  • Fonction : Auteur
Konstantinos H Kastanos
  • Fonction : Auteur
Anthony Lopez
  • Fonction : Auteur
Teresa Mas de Xaxars
  • Fonction : Auteur
Elena Toader
  • Fonction : Auteur

Résumé

The incidence of lymphoproliferative disorders (LD) is increasing in developed countries. Patients with inflammatory bowel disease (IBD) exposed to thiopurines are at additional risk of three specific forms of LD: Epstein-Barr-Virus-related post-transplant like LD, hepato-splenic T-cell lymphoma and post-mononucleosis lymphoproliferation. The risk of the two latter forms of LD can be reduced when considering specific immunosuppressive strategies in young males. It is still unclear whether the risk of uterine cervix abnormalities is increased in IBD women, irrespective of the use of immunosuppressants. Given the excess risk demonstrated in various other contexts of immunosuppression, it is currently recommended that all women with IBD, particularly those receiving immunosuppressants, strictly adhere to a screening program of cervical surveillance and undergo vaccination against HPV, when appropriate. Patients with IBD receiving immunosuppressants are at increased risk of skin cancers. The risk of non-melanoma skin cancer is notably increased in patients receiving thiopurines. Recent data suggest that the risk of melanoma is mildly increased in patients exposed to anti-TNF therapy. All IBD patients should adhere to a program of sun protection and dermatological surveillance, whose details should take into account the other non-IBD-related risk factors.

Domaines

Chimie organique

Dates et versions

hal-00829286 , version 1 (03-06-2013)

Identifiants

Citer

Fernando Magro, Laurent Peyrin-Biroulet, Harry Sokol, Xavier Aldeger, Antonia Costa, et al.. Extra-intestinal malignancies in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (III).. Journal of Crohn's and Colitis, 2013, 4, pp.31-44 ⟨10.1016/j.crohns.2013.04.006⟩. ⟨hal-00829286⟩
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