<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00821159</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T01:55:11+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">In vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity.</title>
            <author role="aut">
              <persName>
                <forename type="first">Ana</forename>
                <surname>Villegas-Mendez</surname>
              </persName>
              <idno type="halauthorid">678338-0</idno>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marina</forename>
                <forename type="middle">I.</forename>
                <surname>Garin</surname>
              </persName>
              <idno type="halauthorid">723209-0</idno>
              <affiliation ref="#struct-1082138"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Estela</forename>
                <surname>Pineda-Molina</surname>
              </persName>
              <idno type="halauthorid">709508-0</idno>
              <affiliation ref="#struct-226972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eugenia</forename>
                <surname>Veratti</surname>
              </persName>
              <idno type="halauthorid">709509-0</idno>
              <affiliation ref="#struct-707"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Juan</forename>
                <forename type="middle">A.</forename>
                <surname>Bueren</surname>
              </persName>
              <idno type="halauthorid">726352-0</idno>
              <affiliation ref="#struct-1082138"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pascal</forename>
                <surname>Fender</surname>
              </persName>
              <email type="md5">61e0f20f56e6d0e04b9e19e2eeaeda59</email>
              <email type="domain">ibs.fr</email>
              <idno type="idhal" notation="string">pascal-fender</idno>
              <idno type="idhal" notation="numeric">12905</idno>
              <idno type="halauthorid" notation="string">24033-12905</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6698-3367</idno>
              <idno type="IDREF">https://www.idref.fr/070009627</idno>
              <idno type="IDREF">https://www.idref.fr/16549140X</idno>
              <affiliation ref="#struct-182981"/>
              <affiliation ref="#struct-576"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Jean-Luc</forename>
                <surname>Lenormand</surname>
              </persName>
              <email type="md5">4cce8fe974f42ff11c70aa071d93e6a9</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">761188</idno>
              <idno type="halauthorid" notation="string">393021-761188</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2766-9180</idno>
              <idno type="IDREF">https://www.idref.fr/14421282X</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6644-2014</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/ABF-3850-2021</idno>
              <idno type="VIAF">https://viaf.org/viaf/281953768</idno>
              <affiliation ref="#struct-388270"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marie-Claire</forename>
                <surname>Dagher</surname>
              </persName>
              <email type="md5">16a92a66fdebde7a6e37680303039cc5</email>
              <email type="domain">ibs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-05-07 16:26:14</date>
              <date type="whenModified">2025-09-27 19:54:10</date>
              <date type="whenReleased">2013-05-07 16:26:14</date>
              <date type="whenProduced">2010-05</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890114"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="140374">
                <persName>
                  <forename>Marie-Claire</forename>
                  <surname>Dagher</surname>
                </persName>
                <email type="md5">16a92a66fdebde7a6e37680303039cc5</email>
                <email type="domain">ibs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00821159</idno>
            <idno type="halUri">https://hal.science/hal-00821159</idno>
            <idno type="halBibtex">villegasmendez:hal-00821159</idno>
            <idno type="halRefHtml">&lt;i&gt;Molecular Therapy&lt;/i&gt;, 2010, 18 (5), pp.1046-53. &lt;a target="_blank" href="https://dx.doi.org/10.1038/mt.2010.16"&gt;&amp;#x27E8;10.1038/mt.2010.16&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecular Therapy, 2010, 18 (5), pp.1046-53. &amp;#x27E8;10.1038/mt.2010.16&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEREX" corresp="TIMC-IMAG">TheREx : Thérapeutique Recombinante Expérimentale</idno>
            <idno type="stamp" n="UVHCI" corresp="CNRS">Unit of Virus Host Cell Interactions</idno>
            <idno type="stamp" n="IBS" corresp="CEA">Institut de Biologie Structurale</idno>
            <idno type="stamp" n="IBS-SAG" corresp="IBS">Groupe Structure et Activité des Glycosaminoglycanes / Structure and Activity of Glycosaminoglycans Group (IBS-SAGAG)</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="IRIG" corresp="CEA">Institut de Recherche Interdisciplinaire de Grenoble</idno>
            <idno type="stamp" n="CEA-GRE" corresp="CEA">CEA Grenoble</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">In vivo delivery of antigens by adenovirus dodecahedron induces cellular and humoral immune responses to elicit antitumor immunity.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Ana</forename>
                    <surname>Villegas-Mendez</surname>
                  </persName>
                  <idno type="halauthorid">678338-0</idno>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marina</forename>
                    <forename type="middle">I.</forename>
                    <surname>Garin</surname>
                  </persName>
                  <idno type="halauthorid">723209-0</idno>
                  <affiliation ref="#struct-1082138"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Estela</forename>
                    <surname>Pineda-Molina</surname>
                  </persName>
                  <idno type="halauthorid">709508-0</idno>
                  <affiliation ref="#struct-226972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eugenia</forename>
                    <surname>Veratti</surname>
                  </persName>
                  <idno type="halauthorid">709509-0</idno>
                  <affiliation ref="#struct-707"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Juan</forename>
                    <forename type="middle">A.</forename>
                    <surname>Bueren</surname>
                  </persName>
                  <idno type="halauthorid">726352-0</idno>
                  <affiliation ref="#struct-1082138"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pascal</forename>
                    <surname>Fender</surname>
                  </persName>
                  <email type="md5">61e0f20f56e6d0e04b9e19e2eeaeda59</email>
                  <email type="domain">ibs.fr</email>
                  <idno type="idhal" notation="string">pascal-fender</idno>
                  <idno type="idhal" notation="numeric">12905</idno>
                  <idno type="halauthorid" notation="string">24033-12905</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6698-3367</idno>
                  <idno type="IDREF">https://www.idref.fr/070009627</idno>
                  <idno type="IDREF">https://www.idref.fr/16549140X</idno>
                  <affiliation ref="#struct-182981"/>
                  <affiliation ref="#struct-576"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Jean-Luc</forename>
                    <surname>Lenormand</surname>
                  </persName>
                  <email type="md5">4cce8fe974f42ff11c70aa071d93e6a9</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">761188</idno>
                  <idno type="halauthorid" notation="string">393021-761188</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2766-9180</idno>
                  <idno type="IDREF">https://www.idref.fr/14421282X</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6644-2014</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/ABF-3850-2021</idno>
                  <idno type="VIAF">https://viaf.org/viaf/281953768</idno>
                  <affiliation ref="#struct-388270"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17194</idno>
                <idno type="issn">1525-0016</idno>
                <idno type="eissn">1525-0024</idno>
                <title level="j">Molecular Therapy</title>
                <imprint>
                  <publisher>Cell Press</publisher>
                  <biblScope unit="volume">18</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">1046-53</biblScope>
                  <date type="datePub">2010-05</date>
                  <date type="dateEpub">2010-02-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/mt.2010.16</idno>
              <idno type="pubmed">20179681</idno>
              <idno type="pubmedcentral">PMC2890114</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adenoviridae</classCode>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">Mice, Inbred C57BL</classCode>
              <classCode scheme="mesh">Ovalbumin</classCode>
              <classCode scheme="mesh">Ubiquitin-Protein Ligases</classCode>
              <classCode scheme="mesh">Viral Proteins</classCode>
              <classCode scheme="mesh">Cancer Vaccines</classCode>
              <classCode scheme="mesh">Endosomal Sorting Complexes Required for Transport</classCode>
              <classCode scheme="mesh">HeLa Cells</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Immunity, Cellular</classCode>
              <classCode scheme="mesh">Immunity, Humoral</classCode>
              <classCode scheme="mesh">Immunotherapy</classCode>
              <classCode scheme="mesh">Melanoma, Experimental</classCode>
              <classCode scheme="halDomain" n="sdv.imm.ii">Life Sciences [q-bio]/Immunology/Innate immunity</classCode>
              <classCode scheme="halDomain" n="sdv.bio">Life Sciences [q-bio]/Biotechnology</classCode>
              <classCode scheme="halDomain" n="info.info-bt">Computer Science [cs]/Biotechnology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Cancer vaccines based on virus-like particles (VLPs) vectors may offer many advantages over other antigen-delivery systems and represent an alternative to the ex vivo cell therapy approach. In this study, we describe the use of penton-dodecahedron (Pt-Dd) VLPs from human adenovirus type 3 (Ad3) as cancer vaccine vehicle for specific antigens, based on its unique cellular internalization properties. WW domains from the ubiquitin ligase Nedd4 serve as an adapter to bind the antigen to Pt-Dd. By engineering fusion partners of WW with the model antigen ovalbumin (OVA), Pt-Dd can efficiently deliver WW-OVA in vitro and the Pt-Dd/WW complex can be readily internalized by dendritic cells (DCs). Immunization with WW-OVA/Pt-Dd results in 90% protection against B16-OVA melanoma implantation in syngeneic mice. This high level of protection correlates with the development of OVA-specific CD8(+) T cells. Moreover, vaccination with WW-OVA Pt-Dd induces robust humoral responses in mice as shown by the high levels of anti-OVA antibodies (Abs) detected in serum. Importantly, treatment of mice bearing B16-OVA tumors with WW-OVA/Pt-Dd results in complete tumor regression in 100% of cases. Thus, our data supports a dual role of Pt-Dd as antigen-delivery vector and natural adjuvant, able to generate integrated cellular and humoral responses of broad immunogenic complexity to elicit specific antitumor immunity. Antigen delivery by Pt-Dd vector is a promising novel strategy for development of cancer vaccines with important clinical applications.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1082138" status="VALID">
          <orgName>Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas</orgName>
          <orgName type="acronym">CIEMAT</orgName>
          <date type="start">1986-01-01</date>
          <desc>
            <address>
              <addrLine>Av. Complutense, 40, 28040 Madrid, Espagne</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.ciemat.es/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-226972" status="VALID">
          <orgName>Laboratorio de Estudios Cristalográficos - LEC (Armilla, Spain)</orgName>
          <desc>
            <address>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-302726" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-182981" status="OLD">
          <idno type="IdRef">20301541X</idno>
          <idno type="RNSR">200919746D</idno>
          <orgName>Unit of Virus Host Cell Interactions = Biologie structurale des interactions entre virus et cellule hôte</orgName>
          <orgName type="acronym">UVHCI</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>6 rue Jules Horowitz, BP 18138042 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.hal.inserm.fr/UVHCI</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-301930" type="direct"/>
            <relation name="UMI3265" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="department" xml:id="struct-576" status="OLD">
          <idno type="IdRef">06912633X</idno>
          <idno type="ISNI">0000 0004 0641 5776</idno>
          <idno type="RNSR">199911764W</idno>
          <idno type="ROR">https://ror.org/04szabx38</idno>
          <orgName>Institut de biologie structurale</orgName>
          <orgName type="acronym">IBS - UMR 5075</orgName>
          <date type="start">1992-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Institut de Biologie Structurale, 71 avenue des martyrs, CS 10090, 38044 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ibs.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR5075 / UPR9015" active="#struct-441569" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
            <relation name="DRF/IRIG/DBSC" active="#struct-555292" type="direct"/>
            <relation name="DRF/IRIG" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388270" status="INCOMING">
          <orgName>TheREx</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302726" status="VALID">
          <idno type="ROR">https://ror.org/04njjy449</idno>
          <orgName>Universidad de Granada = University of Granada</orgName>
          <orgName type="acronym">UGR</orgName>
          <desc>
            <address>
              <addrLine>Avda. del Hospicio, s/n C.P. 18010 Granada</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.ugr.es</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301930" status="VALID">
          <idno type="ROR">https://ror.org/01zjc6908</idno>
          <orgName>European Molecular Biology Laboratory [Grenoble]</orgName>
          <orgName type="acronym">EMBL</orgName>
          <desc>
            <address>
              <addrLine>71 avenue des MartyrsCS 9018138042 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.embl.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-555292" status="VALID">
          <idno type="IdRef">240648846</idno>
          <idno type="RNSR">201923169F</idno>
          <idno type="ROR">https://ror.org/00byxdz40</idno>
          <idno type="Wikidata">Q108737333</idno>
          <orgName>Institut de Recherche Interdisciplinaire de Grenoble</orgName>
          <orgName type="acronym">IRIG</orgName>
          <date type="start">2019-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://hal-cea.archives-ouvertes.fr/IRIG/</ref>
          </desc>
          <listRelation>
            <relation name="DRF/IRIG" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>