Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Annals of Oncology Année : 2012

Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia.

F. Garban
  • Fonction : Auteur
S. Carras
  • Fonction : Auteur
P. Drillat
  • Fonction : Auteur
M. C. Jacob
  • Fonction : Auteur
Benoît Fabre
M. Callanan
  • Fonction : Auteur
S. Courby
  • Fonction : Auteur
C. Makowski
  • Fonction : Auteur
J. Y. Cahn
  • Fonction : Auteur
R. Gressin
  • Fonction : Auteur

Résumé

BACKGROUND: To evaluate the efficacy of extracorporeal photopheresis (ECP) in noncutaneous T-cell lymphoma and large granular lymphocytes leukemia (LGL). PATIENTS AND METHODS: We have treated 12 refractory/relapsed patients. Six peripheral T-cell lymphoma (PTCL), one T-lymphoblastic lymphoma and five LGL with blood involvement received six biweekly leukapheresis as induction phase, followed by one course a week for 4 weeks as consolidation and one course of maintenance per month for responders until progression/relapse or disappearance of the peripheral clone. RESULTS: Six patients responded to phototherapy. Two PTCL and two LGL achieved a complete response (CR) and two other PTCL a partial response. The median duration of CR was 117 months (45-150 months) for these four patients. The peripheral clone followed by flow cytometry decreased in all six responders. Two patients with a complete disappearance of the peripheral clone have not relapsed. CONCLUSIONS: As for cutaneous T-cell lymphoma, ECP therefore to be efficient for PTCL and LGL. Early decrease and disappearance of the peripheral clone were the indicators of clinical response and nonrelapse, respectively.

Domaines

Hématologie

Dates et versions

hal-00821132 , version 1 (07-05-2013)

Identifiants

Citer

F. Garban, S. Carras, P. Drillat, M. C. Jacob, Benoît Fabre, et al.. Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia.. Annals of Oncology, 2012, 23 (9), pp.2386-90. ⟨10.1093/annonc/mds014⟩. ⟨hal-00821132⟩
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