<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00816906</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T14:32:54+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Factor v Leiden homozygous genotype and pregnancy outcomes.</title>
            <author role="crp">
              <persName>
                <forename type="first">Christine</forename>
                <surname>Biron-Andréani</surname>
              </persName>
              <email type="md5">f309fa95fe4e13dabd12bed38a5378d8</email>
              <email type="domain">chu-montpellier.fr</email>
              <idno type="idhal" notation="numeric">944166</idno>
              <idno type="halauthorid" notation="string">726403-944166</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7549-8718</idno>
              <affiliation ref="#struct-162363"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Bauters</surname>
              </persName>
              <idno type="halauthorid">432270-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Véronique</forename>
                <surname>Le Cam-Duchez</surname>
              </persName>
              <idno type="halauthorid">706531-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bénédicte</forename>
                <surname>Delahousse</surname>
              </persName>
              <idno type="halauthorid">626931-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Agnès</forename>
                <surname>Lequerrec</surname>
              </persName>
              <idno type="halauthorid">706532-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabienne</forename>
                <surname>Dutrillaux</surname>
              </persName>
              <idno type="halauthorid">432267-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Boinot</surname>
              </persName>
              <idno type="halauthorid">706533-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Saladin-Thiron</surname>
              </persName>
              <idno type="halauthorid">706534-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoit</forename>
                <surname>Polack</surname>
              </persName>
              <email type="md5">57561dd4fe217a1caf2697ee917e4754</email>
              <email type="domain">chu-grenoble.fr</email>
              <idno type="idhal" notation="numeric">839736</idno>
              <idno type="halauthorid" notation="string">204413-839736</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1697-6249</idno>
              <idno type="IDREF">https://www.idref.fr/059672048</idno>
              <idno type="VIAF">https://viaf.org/viaf/201988847</idno>
              <idno type="ISNI">http://isni.org/isni/0000000357994889</idno>
              <affiliation ref="#struct-388270"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yves</forename>
                <surname>Gruel</surname>
              </persName>
              <email type="md5">a33851b18b70136d42e2a0d8dd2dd48e</email>
              <email type="domain">med.univ-tours.fr</email>
              <idno type="idhal" notation="numeric">929474</idno>
              <idno type="halauthorid" notation="string">202264-929474</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1250-6063</idno>
              <idno type="IDREF">https://www.idref.fr/060594993</idno>
              <affiliation ref="#struct-116570"/>
              <affiliation ref="#struct-415018"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Emmanuel</forename>
                <surname>Morange</surname>
              </persName>
              <email type="md5">785502e2a756212c14e169e8b3da0829</email>
              <email type="domain">ap-hm.fr</email>
              <idno type="idhal" notation="numeric">908932</idno>
              <idno type="halauthorid" notation="string">580248-908932</idno>
              <affiliation ref="#struct-180118"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Benoit</forename>
                <surname>Polack</surname>
              </persName>
              <email type="md5">36c4a5aff3d39b7495c31fba0a1c2857</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-04-23 11:13:30</date>
              <date type="whenModified">2026-04-02 11:00:02</date>
              <date type="whenReleased">2013-04-23 11:13:30</date>
              <date type="whenProduced">2009-12</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="140629">
                <persName>
                  <forename>Benoit</forename>
                  <surname>Polack</surname>
                </persName>
                <email type="md5">36c4a5aff3d39b7495c31fba0a1c2857</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00816906</idno>
            <idno type="halUri">https://hal.science/hal-00816906</idno>
            <idno type="halBibtex">bironandreani:hal-00816906</idno>
            <idno type="halRefHtml">&lt;i&gt;Obstetrics and Gynecology&lt;/i&gt;, 2009, 114 (6), pp.1249-53. &lt;a target="_blank" href="https://dx.doi.org/10.1097/AOG.0b013e3181c2243d"&gt;&amp;#x27E8;10.1097/AOG.0b013e3181c2243d&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Obstetrics and Gynecology, 2009, 114 (6), pp.1249-53. &amp;#x27E8;10.1097/AOG.0b013e3181c2243d&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="UNIV-TOURS">Université François Rabelais</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-THEREX" corresp="TIMC-IMAG">TheREx : Thérapeutique Recombinante Expérimentale</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="UM1-UM2" corresp="UNIV-MONTPELLIER">Université Montpellier 1 - Université Montpellier 2</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Factor v Leiden homozygous genotype and pregnancy outcomes.</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Christine</forename>
                    <surname>Biron-Andréani</surname>
                  </persName>
                  <email type="md5">f309fa95fe4e13dabd12bed38a5378d8</email>
                  <email type="domain">chu-montpellier.fr</email>
                  <idno type="idhal" notation="numeric">944166</idno>
                  <idno type="halauthorid" notation="string">726403-944166</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7549-8718</idno>
                  <affiliation ref="#struct-162363"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Bauters</surname>
                  </persName>
                  <idno type="halauthorid">432270-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Véronique</forename>
                    <surname>Le Cam-Duchez</surname>
                  </persName>
                  <idno type="halauthorid">706531-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bénédicte</forename>
                    <surname>Delahousse</surname>
                  </persName>
                  <idno type="halauthorid">626931-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Agnès</forename>
                    <surname>Lequerrec</surname>
                  </persName>
                  <idno type="halauthorid">706532-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabienne</forename>
                    <surname>Dutrillaux</surname>
                  </persName>
                  <idno type="halauthorid">432267-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Boinot</surname>
                  </persName>
                  <idno type="halauthorid">706533-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Saladin-Thiron</surname>
                  </persName>
                  <idno type="halauthorid">706534-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoit</forename>
                    <surname>Polack</surname>
                  </persName>
                  <email type="md5">57561dd4fe217a1caf2697ee917e4754</email>
                  <email type="domain">chu-grenoble.fr</email>
                  <idno type="idhal" notation="numeric">839736</idno>
                  <idno type="halauthorid" notation="string">204413-839736</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1697-6249</idno>
                  <idno type="IDREF">https://www.idref.fr/059672048</idno>
                  <idno type="VIAF">https://viaf.org/viaf/201988847</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000357994889</idno>
                  <affiliation ref="#struct-388270"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yves</forename>
                    <surname>Gruel</surname>
                  </persName>
                  <email type="md5">a33851b18b70136d42e2a0d8dd2dd48e</email>
                  <email type="domain">med.univ-tours.fr</email>
                  <idno type="idhal" notation="numeric">929474</idno>
                  <idno type="halauthorid" notation="string">202264-929474</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1250-6063</idno>
                  <idno type="IDREF">https://www.idref.fr/060594993</idno>
                  <affiliation ref="#struct-116570"/>
                  <affiliation ref="#struct-415018"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Emmanuel</forename>
                    <surname>Morange</surname>
                  </persName>
                  <email type="md5">785502e2a756212c14e169e8b3da0829</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="idhal" notation="numeric">908932</idno>
                  <idno type="halauthorid" notation="string">580248-908932</idno>
                  <affiliation ref="#struct-180118"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17595</idno>
                <idno type="issn">0029-7844</idno>
                <idno type="eissn">1873-233X</idno>
                <title level="j">Obstetrics and Gynecology</title>
                <imprint>
                  <publisher>Lippincott, Williams &amp; Wilkins</publisher>
                  <biblScope unit="volume">114</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">1249-53</biblScope>
                  <date type="datePub">2009-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1097/AOG.0b013e3181c2243d</idno>
              <idno type="pubmed">19935026</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Cohort Studies</classCode>
              <classCode scheme="mesh">France</classCode>
              <classCode scheme="mesh">Heterozygote</classCode>
              <classCode scheme="mesh">Homozygote</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Pregnancy</classCode>
              <classCode scheme="mesh">Pregnancy Outcome</classCode>
              <classCode scheme="mesh">Retrospective Studies</classCode>
              <classCode scheme="mesh">Embryo Loss</classCode>
              <classCode scheme="mesh">Factor V</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Fetal Death</classCode>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>OBJECTIVE: To assess the rate of early (first trimester) and late (second and third trimester) fetal loss in women who are factor V Leiden homozygous. METHODS: Between December 1995 and February 2007, consecutive, unrelated white women who were factor V Leiden homozygous and who had been pregnant at least once were recruited from 10 French hemostasis units. For reasons of comparison, we included women who were factor V Leiden heterozygous and a group of noncarriers. The frequency of early and late fetal loss was assessed retrospectively and compared among the three groups. The effect of concomitant thrombophilic abnormalities was evaluated. The overall pregnancy outcome was reported. RESULTS: We analyzed 240 thromboprophylaxis-free pregnancies in 95 women who were factor V Leiden homozygous, 425 in 195 women who were factor V Leiden heterozygous, and 182 in 73 women who were noncarriers. The risk of late fetal loss was higher in women who were homozygous (13/95, 13.7%) compared with those who were noncarriers (1/73, 1.4%, odds ratio 11.41, 95% confidence interval 1.46-89.46, P=.002), whereas it was similar in women who were heterozygous and in noncarriers (6/195, 3.1% compared with 1/73, 1.4%, P=.68). The percentage of women with early fetal loss was similar in the three groups (P=.81). The live-birth rate was 80%, 84%, and 85%, respectively, for women who where homozygous, heterozygous, and noncarriers (P=.88). CONCLUSION: The factor V Leiden homozygous genotype increases the risk of late fetal loss. However, the overall likelihood of a positive outcome is high in our series of women who were homozygous. LEVEL OF EVIDENCE: III.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-162363" status="VALID">
          <orgName>Département d'Hématologie biologique [Saint-Eloi - CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>80, avenue Augustin Fliche, 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/offre-de-soins/services/hematologie-biologique-222</ref>
          </desc>
          <listRelation>
            <relation active="#struct-303483" type="direct"/>
            <relation active="#struct-258773" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-388270" status="INCOMING">
          <orgName>TheREx</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-116570" status="VALID">
          <orgName>Service d'hématologie [CHRU Tours]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-179009" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-415018" status="OLD">
          <orgName>Génétique, immunothérapie, chimie et cancer</orgName>
          <orgName type="acronym">GICC</orgName>
          <date type="start">2008-01-01</date>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>UFR de Médecine, Bâtiment Bretonneau, 10 boulevard Tonnellé, BP 3223, 37032 Tours Cedex 01</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR6239" active="#struct-300298" type="direct"/>
            <relation name="UMR6239" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-180118" status="OLD">
          <idno type="IdRef">123019265</idno>
          <idno type="RNSR">197417835D</idno>
          <orgName>Nutrition, obésité et risque thrombotique</orgName>
          <orgName type="acronym">NORT</orgName>
          <date type="start">1974</date>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine Timone - 27 Bd Jean Moulin 13385 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://nort.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_A1260" active="#struct-92114" type="direct"/>
            <relation name="UMR_A1260" active="#struct-198056" type="direct"/>
            <relation name="U1062" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303483" status="VALID">
          <idno type="ROR">https://ror.org/04pwyfk22</idno>
          <orgName>Hôpital Saint Eloi [CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>80 avenue Augustin Fliche - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/decouvrir/etablissements/saint-eloi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-258773" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-258773" status="VALID">
          <idno type="ISNI">000000009961060X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
          <desc>
            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-179009" status="VALID">
          <idno type="ROR">https://ror.org/00jpq0w62</idno>
          <orgName>Centre Hospitalier Régional Universitaire de Tours</orgName>
          <orgName type="acronym">CHRU Tours</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Régional Universitaire de Tours2 Boulevard Tonnellé 37044 Tours cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-tours.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300298" status="VALID">
          <idno type="IdRef">026404478</idno>
          <idno type="ISNI">0000000121608742</idno>
          <idno type="ROR">https://ror.org/02wwzvj46</idno>
          <orgName>Université de Tours</orgName>
          <orgName type="acronym">UT</orgName>
          <date type="start">1970-12-17</date>
          <desc>
            <address>
              <addrLine>60 rue du Plat d'Étain, 37020 Tours cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tours.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>