<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00802859</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T21:30:54+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Antibiotics involved in the occurrence of antibiotic-resistant bacteria: a nationwide multilevel study suggests differences within antibiotic classes.</title>
            <author role="aut">
              <persName>
                <forename type="first">Houssein</forename>
                <surname>Gbaguidi-Haore</surname>
              </persName>
              <idno type="idhal" notation="numeric">759016</idno>
              <idno type="halauthorid" notation="string">366247-759016</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1825-9358</idno>
              <affiliation ref="#struct-57629"/>
              <affiliation ref="#struct-300165"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Dumartin</surname>
              </persName>
              <idno type="halauthorid">587196-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>L'Hériteau</surname>
              </persName>
              <idno type="halauthorid">587197-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Muriel</forename>
                <surname>Péfau</surname>
              </persName>
              <idno type="halauthorid">587198-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Didier</forename>
                <surname>Hocquet</surname>
              </persName>
              <email type="md5">bb8c415063e48ae07650fd99a53bd308</email>
              <email type="domain">chu-besancon.fr</email>
              <idno type="idhal" notation="string">didier-hocquet</idno>
              <idno type="idhal" notation="numeric">760622</idno>
              <idno type="halauthorid" notation="string">366315-760622</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4192-7238</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=Yn8I3XIAAAAJ</idno>
              <idno type="IDREF">https://www.idref.fr/056536852</idno>
              <idno type="VIAF">https://viaf.org/viaf/208795971</idno>
              <idno type="ISNI">http://isni.org/isni/0000000358578553</idno>
              <affiliation ref="#struct-57629"/>
              <affiliation ref="#struct-300165"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne-Marie</forename>
                <surname>Rogues</surname>
              </persName>
              <idno type="halauthorid">495160-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xavier</forename>
                <surname>Bertrand</surname>
              </persName>
              <email type="md5">0ed3c706f485721852cebbba690e71da</email>
              <email type="domain">chu-besancon.fr</email>
              <idno type="idhal" notation="numeric">760618</idno>
              <idno type="halauthorid" notation="string">366250-760618</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8028-1396</idno>
              <idno type="IDREF">https://www.idref.fr/05850463X</idno>
              <idno type="VIAF">https://viaf.org/viaf/5080156012384049700009</idno>
              <affiliation ref="#struct-57629"/>
              <affiliation ref="#struct-300165"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Non</forename>
                <surname>Renseigné</surname>
              </persName>
              <idno type="halauthorid">345197-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Pascal</forename>
                <surname>Cholley</surname>
              </persName>
              <email type="md5">289fb269f92df7cf2b22284a6d51d91a</email>
              <email type="domain">chu-besancon.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-03-20 15:18:16</date>
              <date type="whenModified">2026-05-13 03:25:28</date>
              <date type="whenReleased">2013-03-20 15:18:16</date>
              <date type="whenProduced">2013-02</date>
              <ref type="externalLink" target="https://academic.oup.com/jac/article-pdf/68/2/461/1967845/dks406.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="134320">
                <persName>
                  <forename>Pascal</forename>
                  <surname>Cholley</surname>
                </persName>
                <email type="md5">289fb269f92df7cf2b22284a6d51d91a</email>
                <email type="domain">chu-besancon.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00802859</idno>
            <idno type="halUri">https://hal.science/hal-00802859</idno>
            <idno type="halBibtex">gbaguidihaore:hal-00802859</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Antimicrobial Chemotherapy&lt;/i&gt;, 2013, 68 (2), pp.461-70. &lt;a target="_blank" href="https://dx.doi.org/10.1093/jac/dks406"&gt;&amp;#x27E8;10.1093/jac/dks406&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Antimicrobial Chemotherapy, 2013, 68 (2), pp.461-70. &amp;#x27E8;10.1093/jac/dks406&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Antibiotics involved in the occurrence of antibiotic-resistant bacteria: a nationwide multilevel study suggests differences within antibiotic classes.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Houssein</forename>
                    <surname>Gbaguidi-Haore</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">759016</idno>
                  <idno type="halauthorid" notation="string">366247-759016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1825-9358</idno>
                  <affiliation ref="#struct-57629"/>
                  <affiliation ref="#struct-300165"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Dumartin</surname>
                  </persName>
                  <idno type="halauthorid">587196-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>L'Hériteau</surname>
                  </persName>
                  <idno type="halauthorid">587197-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Muriel</forename>
                    <surname>Péfau</surname>
                  </persName>
                  <idno type="halauthorid">587198-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Didier</forename>
                    <surname>Hocquet</surname>
                  </persName>
                  <email type="md5">bb8c415063e48ae07650fd99a53bd308</email>
                  <email type="domain">chu-besancon.fr</email>
                  <idno type="idhal" notation="string">didier-hocquet</idno>
                  <idno type="idhal" notation="numeric">760622</idno>
                  <idno type="halauthorid" notation="string">366315-760622</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4192-7238</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=Yn8I3XIAAAAJ</idno>
                  <idno type="IDREF">https://www.idref.fr/056536852</idno>
                  <idno type="VIAF">https://viaf.org/viaf/208795971</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000358578553</idno>
                  <affiliation ref="#struct-57629"/>
                  <affiliation ref="#struct-300165"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne-Marie</forename>
                    <surname>Rogues</surname>
                  </persName>
                  <idno type="halauthorid">495160-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xavier</forename>
                    <surname>Bertrand</surname>
                  </persName>
                  <email type="md5">0ed3c706f485721852cebbba690e71da</email>
                  <email type="domain">chu-besancon.fr</email>
                  <idno type="idhal" notation="numeric">760618</idno>
                  <idno type="halauthorid" notation="string">366250-760618</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8028-1396</idno>
                  <idno type="IDREF">https://www.idref.fr/05850463X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/5080156012384049700009</idno>
                  <affiliation ref="#struct-57629"/>
                  <affiliation ref="#struct-300165"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Non</forename>
                    <surname>Renseigné</surname>
                  </persName>
                  <idno type="halauthorid">345197-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15068</idno>
                <idno type="issn">0305-7453</idno>
                <idno type="eissn">1460-2091</idno>
                <title level="j">Journal of Antimicrobial Chemotherapy</title>
                <imprint>
                  <publisher>Oxford University Press (OUP)</publisher>
                  <biblScope unit="volume">68</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">461-70</biblScope>
                  <date type="datePub">2013-02</date>
                  <date type="dateEpub">2012-10-17</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/jac/dks406</idno>
              <idno type="pubmed">23075690</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.mp">Life Sciences [q-bio]/Microbiology and Parasitology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>OBJECTIVES: To identify the antibiotics potentially the most involved in the occurrence of antibiotic-resistant bacteria from an ecological perspective in French healthcare facilities (HCFs). METHODS: This study was based on data from the French antimicrobial surveillance network (ATB-RAISIN, 2007-09). Antibiotics were expressed in defined daily doses per 1000 patient-days. Antibiotic-resistant bacteria were considered as count data adjusted for patient-days. These were third-generation cephalosporin (3GC)- and ciprofloxacin-resistant Escherichia coli, cefotaxime-resistant Enterobacter cloacae, methicillin-resistant Staphylococcus aureus and ceftazidime-, imipenem- and ciprofloxacin-resistant Pseudomonas aeruginosa. Three-level negative binomial regression models were built to take into account the hierarchical structure of data: level 1, repeated measures each year (count outcome, time, antibiotics); level 2, HCFs (type and size); and level 3, regions (geographical area). RESULTS: A total of 701 HCFs from 20 French regions and up to 1339 HCF-years were analysed. The use of ceftriaxone, but not of cefotaxime, was positively correlated with incidence rates of 3GC- and ciprofloxacin-resistant E. coli. In contrast, both 3GCs were positively correlated with the incidence rate of cefotaxime-resistant E. cloacae. Higher levels of use of ciprofloxacin and/or ofloxacin, but not of levofloxacin, were associated with higher incidence rates of 3GC- and ciprofloxacin-resistant E. coli, cefotaxime-resistant E. cloacae, methicillin-resistant S. aureus and ceftazidime- and ciprofloxacin-resistant P. aeruginosa. CONCLUSIONS: Our study suggests differences within antibiotic classes in promoting antibiotic resistance. We identified ceftriaxone, ciprofloxacin and ofloxacin as priority targets in public health strategies designed to reduce antibiotic use and antibiotic-resistant bacteria in French HCFs.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-57629" status="VALID">
          <idno type="IdRef">166212377</idno>
          <idno type="ISNI">0000000103609610</idno>
          <idno type="RNSR">200812285Y</idno>
          <idno type="ROR">https://ror.org/028cef883</idno>
          <orgName>Laboratoire Chrono-environnement (UMR 6249)</orgName>
          <orgName type="acronym">LCE</orgName>
          <date type="start">2008-01-01</date>
          <desc>
            <address>
              <addrLine>16, route de Gray - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://chrono-environnement.univ-fcomte.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR6249" active="#struct-441569" type="direct"/>
            <relation active="#struct-458810" type="direct"/>
            <relation active="#struct-426438" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300165" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Besançon</orgName>
          <orgName type="acronym">CHRU Besançon</orgName>
          <desc>
            <address>
              <addrLine>3, boulevard A. Fleming - 25030 Besançon Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-besancon.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-458810" status="VALID">
          <idno type="IdRef">026403188</idno>
          <idno type="ISNI">0000000121883779</idno>
          <idno type="ROR">https://ror.org/03pcc9z86</idno>
          <orgName>Université Marie et Louis Pasteur</orgName>
          <orgName type="acronym">UMLP</orgName>
          <desc>
            <address>
              <addrLine>1 rue Goudimel25030 Besançon cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.umlp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-426438" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-426438" status="VALID">
          <idno type="IdRef">200716271</idno>
          <idno type="ISNI">0000 0004 4910 6615</idno>
          <idno type="ROR">https://ror.org/02dn7x778</idno>
          <orgName>Université Bourgogne Franche-Comté [COMUE]</orgName>
          <orgName type="acronym">UBFC</orgName>
          <date type="start">2015-04-01</date>
          <date type="end">2024-12-31</date>
          <desc>
            <address>
              <addrLine>32, avenue de l’observatoire25000 BESANCON</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ubfc.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>