Synthesis of Pyrrolin-4-ones by Pt-Catalyzed Cycloisomerization in PEG under Microwaves - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2013

Synthesis of Pyrrolin-4-ones by Pt-Catalyzed Cycloisomerization in PEG under Microwaves

Résumé

The unprecedented eco-friendly Pt-catalyzed 5endo-dig cycloisomerization of readily available α-amino ynones is reported under microwave irradiation in PEG-3400 as reaction matrix. The corresponding pure pyrrolin-4-ones were obtained in excellent yields (80−98%) directly after a straightforward precipitation−filtration workup, thus avoiding any chromatographic purification. The catalytic system was recycled and the chiral purity of all the products was also investigated.

Domaines

Chimie organique
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Dates et versions

hal-00802298 , version 1 (19-03-2013)

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Citer

Rosella Spina, Evelina Colacino, Bartolo Gabriele, Giuseppe Salerno, Jean Martinez, et al.. Synthesis of Pyrrolin-4-ones by Pt-Catalyzed Cycloisomerization in PEG under Microwaves. Journal of Organic Chemistry, 2013, 78 (6), pp.2698-2702. ⟨10.1021/jo302474r⟩. ⟨hal-00802298⟩
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