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Article Dans Une Revue Applied Physics Letters Année : 2012

Mapping of native inorganic elements and injected nanoparticles in a biological organ with laser-induced plasma

Résumé

Emission spectroscopy of laser-induced plasma from a thin section of mouse kidney successfully detected inorganic elements, Na, Ca, Cu, and Gd, naturally contained in the organ or artificially injected in the form of Gd-based nanoparticle. A two-dimensional scan of the sample allowed the laser beam to explore its surface with a resolution of 100 μm, resulting in a quantitative elemental mapping of the organ with sub-mM sensitivity. The compatibility of the setup with standard optical microscopy emphasizes the potential to provide multiple images of a same biological tissue with different types of response which can be elemental, molecular, or cellular.
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Dates et versions

hal-00797906 , version 1 (07-03-2013)

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Vincent Motto-Ros, L. Sancey, L. Ma Q., F. Lux, S. Bai X., et al.. Mapping of native inorganic elements and injected nanoparticles in a biological organ with laser-induced plasma. Applied Physics Letters, 2012, 101 (22), pp.223702. ⟨10.1063/1.4768777⟩. ⟨hal-00797906⟩
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