Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons. - Archive ouverte HAL Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2013

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.

Thomas Roux
  • Function : Author
Eric Trinquet
  • Function : Author
Patrice Mollard

Abstract

To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.

Dates and versions

hal-00796900 , version 1 (05-03-2013)

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Marie Schaeffer, Fanny Langlet, Chrystel Lafont, François Molino, David J Hodson, et al.. Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (4), pp.1512-7. ⟨10.1073/pnas.1212137110⟩. ⟨hal-00796900⟩
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