Article Dans Une Revue Neurological Research Année : 1994

PRELIMINARY-OBSERVATIONS OF METABOLIC CHARACTERIZATION OF BILATERAL TEMPORAL EPILEPTIC FOCUS, USING PROTON MAGNETIC-RESONANCE SPECTROSCOPY - 3 CASES

Résumé

Abstract: The authors report the case of 3 patients with bilateral temporal lobe epilepsy demonstrated by EEG and sphenoidal electrodes. Two out of the 3 patients presented with childhood febrile convulsions. Their neurological and mental examination was normal. EEG showed spikes within the anterior part of the 2 temporal lobes. CT scan and MRI showed no atrophic lesion within the 2 temporal lobes. Proton magnetic resonance spectroscopy, performed within a cube of 8 cube-centimetres localized in the anterior part of the 2 temporal lobes showed a significant decrease of N-acetyl-aspartate in the 2 temporal lobes of the 3 cases, compared with controls matched with age, sex and laterality. Because N-acetyl-aspartate is a marker of the neuronal cells, the decreased level of NAA in the temporal area with spikes, may be rebated to a decreased number of neuronal cells, developing an abnormal tendency to seizures.

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hal-00790134 , version 1 (19-02-2013)

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  • HAL Id : hal-00790134 , version 1

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Maurice Giroud, Paul Walker, David Bernard, Hervé Fayolle, Jacques Beaurain, et al.. PRELIMINARY-OBSERVATIONS OF METABOLIC CHARACTERIZATION OF BILATERAL TEMPORAL EPILEPTIC FOCUS, USING PROTON MAGNETIC-RESONANCE SPECTROSCOPY - 3 CASES. Neurological Research, 1994, 16 (6), pp.481-483. ⟨hal-00790134⟩
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