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Article Dans Une Revue Tetrahedron Année : 2013

Synthesis of novel 3'-methyl-5'-norcarbocyclic nucleoside phosphonates as potential anti-HIV agents

Résumé

Racemic synthesis of novel 3' -methyl-5' -norcarbocyclic nucleoside phosphonates 1aec and 2 was performed using 4-hydroxy-2-methylcyclo-pent-2-enone as starting material. Direct coupling of the heterocyclic base involved a Mitsunobu reaction as key step. The compounds were evaluated for their antiviral properties, but none of them showed significant activity.

Domaines

Chimie organique

Dates et versions

hal-00787223 , version 1 (11-02-2013)

Identifiants

Citer

Jean-Pierre Uttaro, Sylvie Broussous, Christophe Mathe, Christian Perigaud. Synthesis of novel 3'-methyl-5'-norcarbocyclic nucleoside phosphonates as potential anti-HIV agents. Tetrahedron, 2013, 69, pp.2131-2136. ⟨10.1016/j.tet.2013.01.011⟩. ⟨hal-00787223⟩
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