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Article Dans Une Revue Methods in Molecular Biology Année : 2012

Class-specific effector functions of therapeutic antibodies.

Résumé

Physiology usually combines polyclonal antibodies of multiple classes in a single humoral response. Beyond their common ability to bind antigens, these various classes of human immunoglobulins carry specific functions which can each serve specific goals. In many cases, the function of a monoclonal therapeutic antibody may thus be modulated according to the class of its constant domains. Depending on the immunoglobulin class, different functional assays will be used in order to evaluate the functional activity of a monoclonal antibody.

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Immunologie
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Dates et versions

hal-00779398 , version 1 (22-01-2013)

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Virginie Pascal, Brice Laffleur, Michel Cogné. Class-specific effector functions of therapeutic antibodies.. Methods in Molecular Biology, 2012, 901, pp.295-317. ⟨10.1007/978-1-61779-931-0_19⟩. ⟨hal-00779398⟩
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