Protection against reactive oxygen species injuries in rat isolated perfused hearts: effect of LPBNAH, a new amphiphilic spin-trap derived from PBN. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cardiovascular Drugs and Therapy Année : 2006

Protection against reactive oxygen species injuries in rat isolated perfused hearts: effect of LPBNAH, a new amphiphilic spin-trap derived from PBN.

Résumé

Numerous strategies have been designed to protect the myocardium against reactive oxygen species (ROS). The present study was designed to test wether LPBNAH, a new amphiphilic spin-trap derived from PBN is able to protect isolated perfused rat hearts against ROS injuries. Following total glola ischemia (30 min), hearts were reperfused in the presence or not of LPBNAH (10 micromol/l), and left ventricular function was continuously monitored. The addition of LPBNAH led to a significant recovery in left ventricular developped pressure (LVDevP, control: 16.5+/- 7.5, p < 0.05). To conclude, the present results strongly suggest that the modification of previous wellknown molecules in order to facilitate their access to intracellular site of ROS production might be of interest to limit oxidative stresses.

Dates et versions

hal-00776258 , version 1 (15-01-2013)

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Citer

Stéphane Tanguy, Grégory Durand, C. Reboul, Ange Polidori, Bernard Pucci, et al.. Protection against reactive oxygen species injuries in rat isolated perfused hearts: effect of LPBNAH, a new amphiphilic spin-trap derived from PBN.. Cardiovascular Drugs and Therapy, 2006, 20 (2), pp.147-9. ⟨10.1007/s10557-006-6754-8⟩. ⟨hal-00776258⟩
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