Root-knot nematodes are a growing concern for vegetable producers, because chemical nematicides are gradually disappearing. Alternative techniques based on agronomic practices are needed to solve the problem. This review analyzes the most recent studies related to these techniques and their combinations and identifies the most effective ones. Based on an agronomic point of view, the analysis focuses on a description of agricultural factors and practices, rather than on biological processes. Several alternative techniques are considered, including sanitation, soil management, organic amendments, fertilization, biological control and heat-based methods. We analyzed the effects of each practice and interactions among techniques and found large variations among studies. Many practices are only partially effective for nematode control; thus, combining control methods in a systemic analysis presents a challenge. We outline such an ongoing systemic approach and identify key future research studies.