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Journal Articles Journal of Magnetic Resonance Year : 2013

Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot

Abstract

MRI of hyperpolarised gases is usually performed with fast data acquisition to achieve high spatial resolutions despite rapid diffusion-induced signal attenuation. We describe a double-cross k-space sampling scheme suitable for slow low angle shot (SLASH) acquisition and yielding an increased SNR. It consists of a series of anisotropic partial acquisitions with a reduced resolution in the read direction, which alleviates signal attenuation and still provides a high isotropic resolution. The advantages of SLASH imaging over conventional FLASH imaging are evaluated analytically, using numerical lattice calculations, and experimentally in phantom cells filled with hyperpolarised 3He-N2 gas mixtures. Low-field MRI is performed (here 2.7 mT), a necessary condition to obtain long T2* values in lungs for slow acquisition. Two additional benefits of the SLASH scheme over FLASH imaging have been demonstrated: it is less sensitive to the artefacts due to concomitant gradients and it allows measuring apparent diffusion coefficients for an extended range of times.
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Dates and versions

hal-00761896 , version 1 (06-12-2012)

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Kayum Safiullin, Cavin Talbot, Pierre-Jean Nacher. Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot. Journal of Magnetic Resonance, 2013, 227, pp.72-86. ⟨10.1016/j.jmr.2012.11.025⟩. ⟨hal-00761896⟩
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