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Article Dans Une Revue Development (Cambridge, England) Année : 2012

Principles and roles of mRNA localization in animal development.

Caroline Medioni
Kimberly Mowry
  • Fonction : Auteur
Florence Besse

Résumé

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development.

Dates et versions

hal-00760155 , version 1 (03-12-2012)

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Caroline Medioni, Kimberly Mowry, Florence Besse. Principles and roles of mRNA localization in animal development.. Development (Cambridge, England), 2012, 139 (18), pp.3263-76. ⟨10.1242/dev.078626⟩. ⟨hal-00760155⟩
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