Informational suppressor alleles of the eEF1A gene, fertility and cell degeneration in Podospora anserina. - Archive ouverte HAL
Article Dans Une Revue Molecular and General Genetics MGG Année : 2000

Informational suppressor alleles of the eEF1A gene, fertility and cell degeneration in Podospora anserina.

Résumé

Mutations that increase readthrough at a UGA stop codon (informational suppressor mutations) were created in the gene (AS4) that encodes translation elongation factor eEF1A in the filamentous fungus Podospora amserina. The results strongly suggest that the net charge of the eEF1A protein controls the accuracy of translation. Physiological analysis of the mutant strains shows that some of the alleles dominantly increase life span, while only one drastically modifies fertility. This exceptional allele (AS4-56) causes a wide array of phenotypes, including a new growth cessation phenomenon that is different from Senescence or Crippled Growth, previously known degenerative syndromes that are both controlled by AS4. The data emphasise the fact that eEF1A exerts a complex control over cellular physiology.
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Dates et versions

hal-00741896 , version 1 (15-10-2012)

Identifiants

  • HAL Id : hal-00741896 , version 1
  • PUBMED : 11085276

Citer

P. Silar, M. Rossignol, R. Tahar, Z. Derhy, André Mazabraud. Informational suppressor alleles of the eEF1A gene, fertility and cell degeneration in Podospora anserina.. Molecular and General Genetics MGG, 2000, 264 (3), pp.354-62. ⟨hal-00741896⟩
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