<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00741222</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T01:34:13+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study.</title>
            <author role="aut">
              <persName>
                <forename type="first">Antoine</forename>
                <surname>Roquilly</surname>
              </persName>
              <email type="md5">7bf29e731d253d4d9a18f824ab696c69</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">934557</idno>
              <idno type="halauthorid" notation="string">665727-934557</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1029-6242</idno>
              <idno type="IDREF">https://www.idref.fr/14637939X</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre Joachim</forename>
                <surname>Mahe</surname>
              </persName>
              <idno type="halauthorid">665728-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Seguin</surname>
              </persName>
              <idno type="halauthorid">150751-0</idno>
              <affiliation ref="#struct-29275"/>
              <affiliation ref="#struct-106130"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Guitton</surname>
              </persName>
              <email type="md5">65e79fe9c3e4da8e41a1a6d523596e27</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">1395067</idno>
              <idno type="halauthorid" notation="string">55522-1395067</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3517-5009</idno>
              <idno type="IDREF">https://www.idref.fr/093743270</idno>
              <affiliation ref="#struct-200307"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hervé</forename>
                <surname>Floch</surname>
              </persName>
              <idno type="halauthorid">665729-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne Charlotte</forename>
                <surname>Tellier</surname>
              </persName>
              <idno type="halauthorid">665730-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Merson</surname>
              </persName>
              <idno type="halauthorid">665731-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benoît</forename>
                <surname>Renard</surname>
              </persName>
              <idno type="halauthorid">665732-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yannick</forename>
                <surname>Malledant</surname>
              </persName>
              <idno type="halauthorid">665733-0</idno>
              <affiliation ref="#struct-29275"/>
              <affiliation ref="#struct-106130"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laurent</forename>
                <surname>Flet</surname>
              </persName>
              <idno type="halauthorid">665734-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Véronique</forename>
                <surname>Sébille</surname>
              </persName>
              <email type="md5">593b15dd6455203b1e5e42fbef34c0c2</email>
              <email type="domain">univ-nantes.fr</email>
              <idno type="idhal" notation="string">veronique-sebille</idno>
              <idno type="idhal" notation="numeric">182712</idno>
              <idno type="halauthorid" notation="string">8726-182712</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0780-7742</idno>
              <idno type="IDREF">https://www.idref.fr/121997898</idno>
              <affiliation ref="#struct-208116"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christelle</forename>
                <surname>Volteau</surname>
              </persName>
              <idno type="halauthorid">464417-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Damien</forename>
                <surname>Masson</surname>
              </persName>
              <email type="md5">d11818371cd4018349dd03c38e28a8b2</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">971556</idno>
              <idno type="halauthorid" notation="string">17139-971556</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean Michel</forename>
                <surname>Nguyen</surname>
              </persName>
              <idno type="idhal" notation="numeric">1239817</idno>
              <idno type="halauthorid" notation="string">665735-1239817</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8815-7640</idno>
              <idno type="IDREF">https://www.idref.fr/087292335</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Corinne</forename>
                <surname>Lejus</surname>
              </persName>
              <idno type="halauthorid">665736-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Asehnoune</surname>
              </persName>
              <email type="md5">03423effe6aa561dc15ee675350395dd</email>
              <email type="domain">chu-nantes.fr</email>
              <idno type="idhal" notation="numeric">1221700</idno>
              <idno type="halauthorid" notation="string">612322-1221700</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1899-3517</idno>
              <idno type="IDREF">https://www.idref.fr/087986892</idno>
              <affiliation ref="#struct-186609"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Alice</forename>
                <surname>Brébion</surname>
              </persName>
              <email type="md5">3abc06e1ead73f3b204f445606aaba38</email>
              <email type="domain">univ-rennes.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2012-10-12 10:36:59</date>
              <date type="whenModified">2025-07-21 17:46:02</date>
              <date type="whenReleased">2012-10-12 10:36:59</date>
              <date type="whenProduced">2011-03-23</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="167812">
                <persName>
                  <forename>Alice</forename>
                  <surname>Brébion</surname>
                </persName>
                <email type="md5">3abc06e1ead73f3b204f445606aaba38</email>
                <email type="domain">univ-rennes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00741222</idno>
            <idno type="halUri">https://hal.science/hal-00741222</idno>
            <idno type="halBibtex">roquilly:hal-00741222</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of the American Medical Association&lt;/i&gt;, 2011, 305 (12), pp.1201-9. &lt;a target="_blank" href="https://dx.doi.org/10.1001/jama.2011.360"&gt;&amp;#x27E8;10.1001/jama.2011.360&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of the American Medical Association, 2011, 305 (12), pp.1201-9. &amp;#x27E8;10.1001/jama.2011.360&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-NANTES">Université de Nantes</idno>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="IFR140">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno>
            <idno type="stamp" n="HL">Publications CHU Rennes</idno>
            <idno type="stamp" n="U991">U Inserm 991 - Foie, métabolismes et cancer</idno>
            <idno type="stamp" n="U991-E2" corresp="U991">Foie, Métabolismes et Cancer : Equipe Stress, Défenses et Régénération</idno>
            <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno>
            <idno type="stamp" n="LABORATOIRE-MRTE" corresp="UNIV-CERGY">Laboratoire Mobilités Réseaux Territoires Environnement</idno>
            <idno type="stamp" n="NUMECAN">Nutrition, Métabolismes et Cancer</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="TEST-UNIV-RENNES">TEST Université de Rennes</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="SPHERE_HEALTH_RESEARCH">SPHERE MethodS in Patients-centered outcomes and HEalth ResEarch</idno>
            <idno type="stamp" n="NANTES-UNIVERSITE">Nantes Université</idno>
            <idno type="stamp" n="UNIV-NANTES-AV2022">Université de Nantes</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Antoine</forename>
                    <surname>Roquilly</surname>
                  </persName>
                  <email type="md5">7bf29e731d253d4d9a18f824ab696c69</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">934557</idno>
                  <idno type="halauthorid" notation="string">665727-934557</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1029-6242</idno>
                  <idno type="IDREF">https://www.idref.fr/14637939X</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre Joachim</forename>
                    <surname>Mahe</surname>
                  </persName>
                  <idno type="halauthorid">665728-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Seguin</surname>
                  </persName>
                  <idno type="halauthorid">150751-0</idno>
                  <affiliation ref="#struct-29275"/>
                  <affiliation ref="#struct-106130"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Guitton</surname>
                  </persName>
                  <email type="md5">65e79fe9c3e4da8e41a1a6d523596e27</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">1395067</idno>
                  <idno type="halauthorid" notation="string">55522-1395067</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3517-5009</idno>
                  <idno type="IDREF">https://www.idref.fr/093743270</idno>
                  <affiliation ref="#struct-200307"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hervé</forename>
                    <surname>Floch</surname>
                  </persName>
                  <idno type="halauthorid">665729-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne Charlotte</forename>
                    <surname>Tellier</surname>
                  </persName>
                  <idno type="halauthorid">665730-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Merson</surname>
                  </persName>
                  <idno type="halauthorid">665731-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benoît</forename>
                    <surname>Renard</surname>
                  </persName>
                  <idno type="halauthorid">665732-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yannick</forename>
                    <surname>Malledant</surname>
                  </persName>
                  <idno type="halauthorid">665733-0</idno>
                  <affiliation ref="#struct-29275"/>
                  <affiliation ref="#struct-106130"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laurent</forename>
                    <surname>Flet</surname>
                  </persName>
                  <idno type="halauthorid">665734-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Véronique</forename>
                    <surname>Sébille</surname>
                  </persName>
                  <email type="md5">593b15dd6455203b1e5e42fbef34c0c2</email>
                  <email type="domain">univ-nantes.fr</email>
                  <idno type="idhal" notation="string">veronique-sebille</idno>
                  <idno type="idhal" notation="numeric">182712</idno>
                  <idno type="halauthorid" notation="string">8726-182712</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0780-7742</idno>
                  <idno type="IDREF">https://www.idref.fr/121997898</idno>
                  <affiliation ref="#struct-208116"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christelle</forename>
                    <surname>Volteau</surname>
                  </persName>
                  <idno type="halauthorid">464417-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Damien</forename>
                    <surname>Masson</surname>
                  </persName>
                  <email type="md5">d11818371cd4018349dd03c38e28a8b2</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">971556</idno>
                  <idno type="halauthorid" notation="string">17139-971556</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean Michel</forename>
                    <surname>Nguyen</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1239817</idno>
                  <idno type="halauthorid" notation="string">665735-1239817</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8815-7640</idno>
                  <idno type="IDREF">https://www.idref.fr/087292335</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Corinne</forename>
                    <surname>Lejus</surname>
                  </persName>
                  <idno type="halauthorid">665736-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Asehnoune</surname>
                  </persName>
                  <email type="md5">03423effe6aa561dc15ee675350395dd</email>
                  <email type="domain">chu-nantes.fr</email>
                  <idno type="idhal" notation="numeric">1221700</idno>
                  <idno type="halauthorid" notation="string">612322-1221700</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1899-3517</idno>
                  <idno type="IDREF">https://www.idref.fr/087986892</idno>
                  <affiliation ref="#struct-186609"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">5754</idno>
                <idno type="issn">0098-7484</idno>
                <idno type="eissn">1538-3598</idno>
                <title level="j">Journal of the American Medical Association</title>
                <imprint>
                  <publisher>American Medical Association (AMA)</publisher>
                  <biblScope unit="volume">305</biblScope>
                  <biblScope unit="issue">12</biblScope>
                  <biblScope unit="pp">1201-9</biblScope>
                  <date type="datePub">2011-03-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1001/jama.2011.360</idno>
              <idno type="pubmed">21427372</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adolescent</classCode>
              <classCode scheme="mesh">Adrenal Insufficiency</classCode>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Anti-Inflammatory Agents</classCode>
              <classCode scheme="mesh">Cross Infection</classCode>
              <classCode scheme="mesh">Double-Blind Method</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Hydrocortisone</classCode>
              <classCode scheme="mesh">Infusions, Intravenous</classCode>
              <classCode scheme="mesh">Intensive Care Units</classCode>
              <classCode scheme="mesh">Intubation, Intratracheal</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Multiple Trauma</classCode>
              <classCode scheme="mesh">Pneumonia</classCode>
              <classCode scheme="mesh">Respiration, Artificial</classCode>
              <classCode scheme="mesh">Young Adult</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.heg">Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>CONTEXT: The role of stress-dose hydrocortisone in the management of trauma patients is currently unknown. OBJECTIVE: To test the efficacy of hydrocortisone therapy in trauma patients. DESIGN, SETTING, AND PATIENTS: Multicenter, randomized, double-blind, placebo-controlled HYPOLYTE (Hydrocortisone Polytraumatise) study. From November 2006 to August 2009, 150 patients with severe trauma were included in 7 intensive care units in France. INTERVENTION: Patients were randomly assigned to a continuous intravenous infusion of either hydrocortisone (200 mg/d for 5 days, followed by 100 mg on day 6 and 50 mg on day 7) or placebo. The treatment was stopped if patients had an appropriate adrenal response. MAIN OUTCOME MEASURE: Hospital-acquired pneumonia within 28 days. Secondary outcomes included the duration of mechanical ventilation, hyponatremia, and death. RESULTS: One patient withdrew consent. An intention-to-treat (ITT) analysis included the 149 patients, a modified ITT analysis included 113 patients with corticosteroid insufficiency. In the ITT analysis, 26 of 73 patients (35.6%) treated with hydrocortisone and 39 of 76 patients (51.3%) receiving placebo developed hospital-acquired pneumonia by day 28 (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.30-0.83; P = .007). In the modified ITT analysis, 20 of 56 patients (35.7%) in the hydrocortisone group and 31 of 57 patients (54.4%) in the placebo group developed hospital-acquired pneumonia by day 28 (HR, 0.47; 95% CI, 0.25-0.86; P = .01). Mechanical ventilation-free days increased with hydrocortisone by 4 days (95% CI, 2-7; P = .001) in the ITT analysis and 6 days (95% CI, 2-11; P &lt; .001) in the modified ITT analysis. Hyponatremia was observed in 7 of 76 (9.2%) in the placebo group vs none in the hydrocortisone group (absolute difference, -9%; 95% CI, -16% to -3%; P = .01). Four of 76 patients (5.3%) in the placebo group and 6 of 73 (8.2%) in the hydrocortisone group died (absolute difference, 3%; 95% CI, -5% to 11%; P = .44). CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00563303.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-29275" status="VALID">
          <orgName>Service d'anesthésie réanimation chirurgicale [Rennes]</orgName>
          <desc>
            <address>
              <addrLine>2 rue Henri Le Guilloux 35033 RENNES cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-rennes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301327" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-106130" status="OLD">
          <orgName>Foie, métabolismes et cancer</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <addrLine>Hôpital Pontchaillou Rue Henri Le Guilloux 35033 Rennes Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://insermu991.univ-rennes1.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation name="U991" active="#struct-303623" type="direct"/>
            <relation active="#struct-453207" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-200307" status="INCOMING">
          <orgName>Service de Réanimation Médicale</orgName>
          <desc>
            <address>
              <addrLine>1 place Alexis-Ricordeau, Nantes, 44093</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300142" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-208116" status="OLD">
          <orgName>Biostatistique, pharmacoépidémiologie et mesures subjectives en santé</orgName>
          <orgName type="acronym">EA 4275</orgName>
          <date type="start">2008-01-01</date>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>1 rue Gaston Veil 44035 Nantes cedex 01</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-534285" type="direct"/>
            <relation name="93263" active="#struct-93263" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-186609" status="VALID">
          <orgName>Service d'anesthésie et réanimation chirurgicale [Nantes]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300142" type="direct"/>
            <relation active="#struct-474972" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301327" status="VALID">
          <idno type="ROR">https://ror.org/05qec5a53</idno>
          <orgName>Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]</orgName>
          <desc>
            <address>
              <addrLine>2 Rue Henri le Guilloux, 35000 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-453207" status="VALID">
          <idno type="IdRef">200295462</idno>
          <idno type="RNSR">201220717W</idno>
          <idno type="ROR">https://ror.org/05cx7ek10</idno>
          <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes</orgName>
          <orgName type="acronym">Biosit : Biologie - Santé - Innovation Technologique</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Rennes - Campus Santé Villejean -  2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://biosit.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300142" status="VALID">
          <orgName>Hôtel-Dieu</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-474972" status="VALID">
          <idno type="IdRef">034926445</idno>
          <idno type="ROR">https://ror.org/05c1qsg97</idno>
          <idno type="Wikidata">Q2945767</idno>
          <orgName>Centre Hospitalier Universitaire de Nantes = Nantes University Hospital</orgName>
          <orgName type="acronym">CHU Nantes</orgName>
          <desc>
            <address>
              <addrLine>1 Place Alexis-Ricordeau, 44000 Nantes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-nantes.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-534285" status="OLD">
          <orgName>Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques</orgName>
          <orgName type="acronym">UFR SPB</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>9 rue Bias - BP 61112 - 44035 Nantes Cedex1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.pharmacie.univ-nantes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="93263" active="#struct-93263" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93263" status="OLD">
          <idno type="IdRef">026403447</idno>
          <idno type="ROR">https://ror.org/03gnr7b55</idno>
          <orgName>Université de Nantes</orgName>
          <orgName type="acronym">UN</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-nantes.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>