Catalyst- and Halogen-Free Regioselective Friedel-Crafts alpha-Ketoacylations
Résumé
Highly regio- selective and efficient catalyst- and halogen-free Friedel-Crafts alpha-ketoacy- lation reactions leading to heterocycles functionalized with a very versatile 1,3- diketone moiety are described. The reactions rely on microwave-assisted domino Wolff rearrangement/Friedel- Crafts sequences from 2-diazo-1,3- diketones via transient, highly reactive alpha-keto ketene intermediates.