<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00723104</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-01T22:09:26+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Hyperthermia stimulates HIV-1 replication.</title>
            <author role="aut">
              <persName>
                <forename type="first">Ferdinand</forename>
                <surname>Roesch</surname>
              </persName>
              <email type="md5">1d7c0c98d0f4f807c6167ae1281feb45</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">roesch-ferdinand</idno>
              <idno type="idhal" notation="numeric">751891</idno>
              <idno type="halauthorid" notation="string">9169-751891</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0702-7778</idno>
              <affiliation ref="#struct-35824"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Oussama</forename>
                <surname>Meziane</surname>
              </persName>
              <idno type="halauthorid">625796-0</idno>
              <affiliation ref="#struct-425"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anna</forename>
                <surname>Kula</surname>
              </persName>
              <idno type="halauthorid">453480-0</idno>
              <affiliation ref="#struct-204155"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Nisole</surname>
              </persName>
              <email type="md5">ba283d123c45017e5c78255074992b21</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">sebastien-nisole</idno>
              <idno type="idhal" notation="numeric">756629</idno>
              <idno type="halauthorid" notation="string">150719-756629</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9793-419X</idno>
              <idno type="IDREF">https://www.idref.fr/089041496</idno>
              <affiliation ref="#struct-175836"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Françoise</forename>
                <surname>Porrot</surname>
              </persName>
              <email type="md5">aea480a005d7584b556d1bd288f700c7</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">944191</idno>
              <idno type="halauthorid" notation="string">117431-944191</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8995-3614</idno>
              <affiliation ref="#struct-35824"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ian</forename>
                <surname>Anderson</surname>
              </persName>
              <idno type="halauthorid">663264-0</idno>
              <affiliation ref="#struct-204156"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabrizio</forename>
                <surname>Mammano</surname>
              </persName>
              <email type="md5">8de740e0586eef427db8e9bc9cc50473</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">759197</idno>
              <idno type="halauthorid" notation="string">252127-759197</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9193-7696</idno>
              <idno type="IDREF">https://www.idref.fr/142490016</idno>
              <affiliation ref="#struct-81451"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ariberto</forename>
                <surname>Fassati</surname>
              </persName>
              <idno type="halauthorid">663322-0</idno>
              <affiliation ref="#struct-204156"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alessandro</forename>
                <surname>Marcello</surname>
              </persName>
              <idno type="halauthorid">627201-0</idno>
              <affiliation ref="#struct-188752"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Monsef</forename>
                <surname>Benkirane</surname>
              </persName>
              <email type="md5">ed19176c51fd70dea25fd6f05a839d01</email>
              <email type="domain">igh.cnrs.fr</email>
              <idno type="idhal" notation="numeric">1308741</idno>
              <idno type="halauthorid" notation="string">125442-1308741</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8286-4405</idno>
              <idno type="IDREF">https://www.idref.fr/070127131</idno>
              <affiliation ref="#struct-425"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Schwartz</surname>
              </persName>
              <email type="md5">fe5083020856ea33a909646be8fe5974</email>
              <email type="domain">pasteur.fr</email>
              <idno type="idhal" notation="numeric">999827</idno>
              <idno type="halauthorid" notation="string">217629-999827</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0729-1475</idno>
              <idno type="IDREF">https://www.idref.fr/128673850</idno>
              <affiliation ref="#struct-35824"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Catherine</forename>
                <surname>Larose</surname>
              </persName>
              <email type="md5">e018e1da2ed6c016ee0b963c289bbee0</email>
              <email type="domain">igh.cnrs.fr.invalid</email>
            </editor>
            <funder>This work was supported by grants from the Agence Nationale de Recherche sur le SIDA (ANRS), the Agence Nationale de Recherche (ANR), SIDACTION, the Ecole Normale Supe'rieure de Lyon (ENS Lyon), CNRS, AREVA, the Labex IBEID program, Institut Pasteur and the Medical Research Council (MRC).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2012-10-02 12:18:21</date>
              <date type="whenModified">2026-02-03 10:32:32</date>
              <date type="whenReleased">2012-10-02 16:17:55</date>
              <date type="whenProduced">2012-07</date>
              <date type="whenEndEmbargoed">2012-10-02</date>
              <ref type="file" target="https://hal.science/hal-00723104v1/document">
                <date notBefore="2012-10-02"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-00723104v1/file/journal.ppat.1002792.pdf" id="file-723104-299359">
                <date notBefore="2012-10-02"/>
              </ref>
              <ref type="externalLink" target="https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002792&amp;type=printable"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="104009">
                <persName>
                  <forename>Catherine</forename>
                  <surname>Larose</surname>
                </persName>
                <email type="md5">e018e1da2ed6c016ee0b963c289bbee0</email>
                <email type="domain">igh.cnrs.fr.invalid</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00723104</idno>
            <idno type="halUri">https://hal.science/hal-00723104</idno>
            <idno type="halBibtex">roesch:hal-00723104</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS Pathogens&lt;/i&gt;, 2012, 8 (7), pp.e1002792. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.ppat.1002792"&gt;&amp;#x27E8;10.1371/journal.ppat.1002792&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS Pathogens, 2012, 8 (7), pp.e1002792. &amp;#x27E8;10.1371/journal.ppat.1002792&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-723104-299359"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="PASTEUR">Institut Pasteur</idno>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="IGH" corresp="UNIV-MONTPELLIER">Institut de génétique humaine</idno>
            <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Hyperthermia stimulates HIV-1 replication.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Ferdinand</forename>
                    <surname>Roesch</surname>
                  </persName>
                  <email type="md5">1d7c0c98d0f4f807c6167ae1281feb45</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">roesch-ferdinand</idno>
                  <idno type="idhal" notation="numeric">751891</idno>
                  <idno type="halauthorid" notation="string">9169-751891</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0702-7778</idno>
                  <affiliation ref="#struct-35824"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Oussama</forename>
                    <surname>Meziane</surname>
                  </persName>
                  <idno type="halauthorid">625796-0</idno>
                  <affiliation ref="#struct-425"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anna</forename>
                    <surname>Kula</surname>
                  </persName>
                  <idno type="halauthorid">453480-0</idno>
                  <affiliation ref="#struct-204155"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Nisole</surname>
                  </persName>
                  <email type="md5">ba283d123c45017e5c78255074992b21</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">sebastien-nisole</idno>
                  <idno type="idhal" notation="numeric">756629</idno>
                  <idno type="halauthorid" notation="string">150719-756629</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9793-419X</idno>
                  <idno type="IDREF">https://www.idref.fr/089041496</idno>
                  <affiliation ref="#struct-175836"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Françoise</forename>
                    <surname>Porrot</surname>
                  </persName>
                  <email type="md5">aea480a005d7584b556d1bd288f700c7</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">944191</idno>
                  <idno type="halauthorid" notation="string">117431-944191</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8995-3614</idno>
                  <affiliation ref="#struct-35824"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ian</forename>
                    <surname>Anderson</surname>
                  </persName>
                  <idno type="halauthorid">663264-0</idno>
                  <affiliation ref="#struct-204156"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrizio</forename>
                    <surname>Mammano</surname>
                  </persName>
                  <email type="md5">8de740e0586eef427db8e9bc9cc50473</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">759197</idno>
                  <idno type="halauthorid" notation="string">252127-759197</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9193-7696</idno>
                  <idno type="IDREF">https://www.idref.fr/142490016</idno>
                  <affiliation ref="#struct-81451"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ariberto</forename>
                    <surname>Fassati</surname>
                  </persName>
                  <idno type="halauthorid">663322-0</idno>
                  <affiliation ref="#struct-204156"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alessandro</forename>
                    <surname>Marcello</surname>
                  </persName>
                  <idno type="halauthorid">627201-0</idno>
                  <affiliation ref="#struct-188752"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Monsef</forename>
                    <surname>Benkirane</surname>
                  </persName>
                  <email type="md5">ed19176c51fd70dea25fd6f05a839d01</email>
                  <email type="domain">igh.cnrs.fr</email>
                  <idno type="idhal" notation="numeric">1308741</idno>
                  <idno type="halauthorid" notation="string">125442-1308741</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8286-4405</idno>
                  <idno type="IDREF">https://www.idref.fr/070127131</idno>
                  <affiliation ref="#struct-425"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Schwartz</surname>
                  </persName>
                  <email type="md5">fe5083020856ea33a909646be8fe5974</email>
                  <email type="domain">pasteur.fr</email>
                  <idno type="idhal" notation="numeric">999827</idno>
                  <idno type="halauthorid" notation="string">217629-999827</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0729-1475</idno>
                  <idno type="IDREF">https://www.idref.fr/128673850</idno>
                  <affiliation ref="#struct-35824"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">1959</idno>
                <idno type="issn">1553-7366</idno>
                <idno type="eissn">1553-7374</idno>
                <title level="j">PLoS Pathogens</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">8</biblScope>
                  <biblScope unit="issue">7</biblScope>
                  <biblScope unit="pp">e1002792</biblScope>
                  <date type="datePub">2012-07</date>
                  <date type="dateEpub">2012-07-12</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.ppat.1002792</idno>
              <idno type="pubmed">22807676</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.gen">Life Sciences [q-bio]/Genetics</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>HIV-infected individuals may experience fever episodes. Fever is an elevation of the body temperature accompanied by inflammation. It is usually beneficial for the host through enhancement of immunological defenses. In cultures, transient non-physiological heat shock (42-45°C) and Heat Shock Proteins (HSPs) modulate HIV-1 replication, through poorly defined mechanisms. The effect of physiological hyperthermia (38-40°C) on HIV-1 infection has not been extensively investigated. Here, we show that culturing primary CD4+ T lymphocytes and cell lines at a fever-like temperature (39.5°C) increased the efficiency of HIV-1 replication by 2 to 7 fold. Hyperthermia did not facilitate viral entry nor reverse transcription, but increased Tat transactivation of the LTR viral promoter. Hyperthermia also boosted HIV-1 reactivation in a model of latently-infected cells. By imaging HIV-1 transcription, we further show that Hsp90 co-localized with actively transcribing provirus, and this phenomenon was enhanced at 39.5°C. The Hsp90 inhibitor 17-AAG abrogated the increase of HIV-1 replication in hyperthermic cells. Altogether, our results indicate that fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-35824" status="OLD">
          <idno type="RNSR">200718194A</idno>
          <orgName>Virus et Immunité</orgName>
          <desc>
            <address>
              <addrLine>28, rue du docteur Roux F-75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation name="URA3015" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-425" status="OLD">
          <idno type="ISNI">0000000098865504</idno>
          <idno type="RNSR">201722404H</idno>
          <idno type="ROR">https://ror.org/05ee10k25</idno>
          <orgName>Institut de génétique humaine</orgName>
          <orgName type="acronym">IGH</orgName>
          <date type="start">1998-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.igh.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR9002 / UPR1142" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-204155" status="INCOMING">
          <orgName>Laboratory of Molecular Virology</orgName>
          <desc>
            <address>
              <addrLine>Trieste</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-322248" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-175836" status="OLD">
          <orgName>Virologie moléculaire et vaccinologie</orgName>
          <desc>
            <address>
              <addrLine>Département Virologie, 25-28 rue du Dr Roux 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300027" type="direct"/>
            <relation name="URA3015" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-204156" status="INCOMING">
          <orgName>Wohl Virion Centre, Division of Infection and Immunity</orgName>
          <desc>
            <address>
              <addrLine>MRC Centre for Medical &amp; Molecular Virology, London</addrLine>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300875" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-81451" status="OLD">
          <idno type="IdRef">224888781</idno>
          <idno type="RNSR">200920726U</idno>
          <orgName>Génétique et Ecologie des Virus, Génétique des Virus et Pathogénèse des Maladies Virales</orgName>
          <date type="end">2018-12-31</date>
          <desc>
            <address>
              <addrLine>Université Paris Diderot, Institut Universitaire d'Hématologie (IUH), Hôpital Saint Louis 1 avenue Claude Vellefaux 75010 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300301" type="direct"/>
            <relation name="U941" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-188752" status="INCOMING">
          <orgName>Laboratory of Molecular Virology</orgName>
          <desc>
            <address>
              <addrLine>Trieste</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-322248" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300027" status="VALID">
          <idno type="IdRef">027936643</idno>
          <idno type="ISNI">0000 0001 2353 6535</idno>
          <idno type="ROR">https://ror.org/0495fxg12</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <orgName type="acronym">IP</orgName>
          <date type="start">1887-06-04</date>
          <desc>
            <address>
              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-322248" status="VALID">
          <orgName>International Centre for Genetic Engineering and Biotechnology [Trieste, Italy]</orgName>
          <orgName type="acronym">ICGEB</orgName>
          <desc>
            <address>
              <addrLine>Località Padriciano, 99, 34149 Trieste TS, Italie</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.icgeb.org/location/trieste/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300875" status="VALID">
          <idno type="IdRef">029789753</idno>
          <idno type="ROR">https://ror.org/02jx3x895</idno>
          <orgName>University College London [UCL]</orgName>
          <orgName type="acronym">UCL</orgName>
          <desc>
            <address>
              <addrLine>Gower Street, London WC1E 6BT</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.ucl.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>