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Article Dans Une Revue European Journal of Organic Chemistry Année : 2011

Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry

Résumé

The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.

Dates et versions

hal-00720537 , version 1 (24-07-2012)

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Citer

Mathieu Berchel, Jean-Piere Haelters, Hélène Couthon, Laure Burel-Deschamps, Patrick Midoux, et al.. Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry. European Journal of Organic Chemistry, 2011, 31, pp.6294-6303. ⟨10.1002/ejoc.201100900⟩. ⟨hal-00720537⟩
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