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Communication Dans Un Congrès Année : 2012

Microarchitecture of irradiated bone: comparison with healthy bone

Résumé

The squamous cell carcinomas of the upper aero-digestive tract represent about ten percent of cancers. External radiation therapy leads to esthetic and functional consequences, and to a decrease of the bone mechanical abilities. For these patients, the oral prosthetic rehabilitation, including possibilities of dental implant placement, is difficult. The effects of radiotherapy on bone microarchitecture parameters are not well known. Thus, the purpose of this study is to assess the effects of external radiation on bone micro architecture in an experimental model of 25 rats using micro CT. 15 rats were irradiated on the hind limbs by a single dose of 20 Grays, and 10 rats were non irradiated. Images of irradiated and healthy bone were compared. Bone microarchitecture parameters (including trabecular thickness, trabecular number, trabecular separation, connectivity density and tissue and bone volume) between irradiated and non-irradiated bones were calculated and compared using a Mann and Whitney test. After 7 and 12 weeks, images of irradiated and healthy bone are different. Differences on the irradiated and the healthy bone populations exhibit a statistical significance. Trabecular number, connectivity density and closed porosity are less important on irradiated bone. Trabecular thickness and separation increase for irradiated bone. These parameters indicate a decrease of irradiated bone properties. Finally, the external irradiation induces changes on the bone micro architecture. This knowledge is of prime importance for better oral prosthetic rehabilitation, including implant placement.
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Dates et versions

hal-00716917 , version 1 (11-07-2012)

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Pauline Bléry, Yves Amouriq, Jeanpierre Guédon, Paul Pilet, Nicolas Normand, et al.. Microarchitecture of irradiated bone: comparison with healthy bone. SPIE Medical Imaging, Feb 2012, San Diego, United States. pp.831719, ⟨10.1117/12.911375⟩. ⟨hal-00716917⟩
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