Calcium phosphate porous pellets as drug delivery systems : effect of drug carrier composition on drug loading and in vitro release - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the European Ceramic Society Année : 2012

Calcium phosphate porous pellets as drug delivery systems : effect of drug carrier composition on drug loading and in vitro release

Hiva Baradari
  • Fonction : Auteur
  • PersonId : 929135
Chantal Damia
Nathalie Pecout
  • Fonction : Auteur
  • PersonId : 929247
Eric Champion
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  • PersonId : 915683
Dominique Chulia
  • Fonction : Auteur
  • PersonId : 929100
Marylène Viana
  • Fonction : Auteur
  • PersonId : 929136

Résumé

Drug loaded porous calcium phosphate bone substitutes are studied for targeted drug delivery applications. In this study, porous hydroxyapatite and beta-tricalcium phosphate pellets were investigated as anti-inflammatory drug carriers and their ibuprofen adsorption and release properties were compared. While the adsorption equilibrium time of 1 h was obtained for both pellets, hydroxyapatite pellets showed a higher adsorption capacity than beta-tricalcium phosphate. The physico-chemical characterisations of loaded pellets confirmed an ibuprofen reversible physisorption on both hydroxyapatite and beta-tricalcium phosphate pellets. Moreover, higher adsorption capacity of hydroxyapatite was attributed to their physical differences. The in vitro ibuprofen release evaluation showed 100% release of ibuprofen from both hydroxyapatite and beta-tricalcium phosphate pellets which was found to be compatible with the obtained interactions between the pellets and ibuprofen.

Dates et versions

hal-00709454 , version 1 (18-06-2012)

Identifiants

Citer

Hiva Baradari, Chantal Damia, Maggy Colas, Etienne Laborde, Nathalie Pecout, et al.. Calcium phosphate porous pellets as drug delivery systems : effect of drug carrier composition on drug loading and in vitro release. Journal of the European Ceramic Society, 2012, 32, pp.2679-2690. ⟨10.1016/j.jeurceramsoc.2012.01.018⟩. ⟨hal-00709454⟩
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