Article Dans Une Revue Diagnostic Microbiology and Infectious Disease Année : 2012

Impact of yeast-bacteria coinfection on the detection of Candida sp. in an automated blood culture system.

Anne-Sophie Cognee
  • Fonction : Auteur
Tri Cong Tran
  • Fonction : Auteur
Elodie Vallade
  • Fonction : Auteur
Magali Garcia
Sorya Belaz
  • Fonction : Auteur
Catherine Kauffmann-Lacroix
  • Fonction : Auteur
  • PersonId : 1488909
  • IdRef : 073283657

Résumé

Invasive candidiasis remains a major cause of morbidity and mortality. It is now well known that an early diagnosis contributes to the patients' outcome. Blood cultures, which are the first-line test in case of bloodstream infection suspicion, can be carried out using fungus-selective medium (containing antibiotics) or standard microorganism medium allowing both bacterial and fungal growth. Some patients can suffer from polymicrobial sepsis involving bacteria and yeasts, so we decided to investigate in blood cultures the influence of the presence of bacteria on fungal development. Simulated blood cultures were performed using Candida albicans or C. glabrata coincubated with Escherichia coli or Staphylococcus aureus at different concentrations. The results showed that, in a standard microorganism medium, bacterial growth could hide the fungal development. Thus, in patients at risk of invasive candidiasis, the use of a specific fungal medium could improve the diagnosis and allow an earlier efficient antifungal treatment.

Dates et versions

hal-00707687 , version 1 (13-06-2012)

Identifiants

Citer

Estelle Cateau, Anne-Sophie Cognee, Tri Cong Tran, Elodie Vallade, Magali Garcia, et al.. Impact of yeast-bacteria coinfection on the detection of Candida sp. in an automated blood culture system.. Diagnostic Microbiology and Infectious Disease, 2012, 72 (4), pp.328-31. ⟨10.1016/j.diagmicrobio.2011.12.012⟩. ⟨hal-00707687⟩
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