Situational method engineering (SME) is concerned with the design, construction, and evaluation of methods that are aimed at the development of particular software products in well-defined development situations. The SME approach features characteristics such as flexibility, adaptability, modularity, reusability, and reference to situational aspects. These aspects may not only be useful for the engineering of software but also for the engineering of work systems, organizational structures, or enterprises. This paper therefore presents exemplary applications of the SME approach in domains that are different from software engineering. It furthermore discusses potentials and limitations of the transfer and application of SME principles, concepts, and techniques to those subject areas.