Rapid and Efficient Synthesis of Unsymmetrical Phosphinic Acids R ' P(O)OHR ''
Résumé
A new synthesis of unsymmetrical phosphinic acids R'P(O)OHR '' has been evaluated. The first P-C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle. A one-pot methodology was developed for the second P-C bond formation reaction that involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid with an amino functionality. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)