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Article Dans Une Revue European Journal of Organic Chemistry Année : 2009

Rapid and Efficient Synthesis of Unsymmetrical Phosphinic Acids R ' P(O)OHR ''

Résumé

A new synthesis of unsymmetrical phosphinic acids R'P(O)OHR '' has been evaluated. The first P-C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle. A one-pot methodology was developed for the second P-C bond formation reaction that involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid with an amino functionality. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

Dates et versions

hal-00705492 , version 1 (07-06-2012)

Identifiants

Citer

C. Fougere, E. Guenin, J. Hardouin, M. Lecouvey. Rapid and Efficient Synthesis of Unsymmetrical Phosphinic Acids R ' P(O)OHR ''. European Journal of Organic Chemistry, 2009, 34, pp.6048-6054. ⟨10.1002/ejoc.200900852⟩. ⟨hal-00705492⟩
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