Expression of functional soluble human leucocyte antigen-G molecules in lymphoproliferative disorders. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue British Journal of Haematology Année : 2007

Expression of functional soluble human leucocyte antigen-G molecules in lymphoproliferative disorders.

Résumé

Membrane-bound and soluble human leucocyte antigen-G (sHLA-G) molecules display immunotolerant properties favouring tumour cell escape from immune surveillance. sHLA-G molecules have been detected in several tumour pathologies; this study aimed to evaluate sHLA-G expression in lymphoproliferative disorders. sHLA-G plasma level was significantly increased in 110 of 178 newly diagnosed lymphoid proliferations cases i.e. 59% of chronic lymphocytic leukaemia, 65% of B non-Hodgkin lymphomas (NHL) and 58% of T-NHL. To assess the mechanisms involved in this secretion, the differential effect of cytokines was tested in in vitro cultures of NHL cells. A significant induction of sHLA-G level was shown in T-NHL in contrast with B-NHL and normal equivalent cells, after cytokine stimulation with (i) interferongamma (IFNgamma), interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor, (ii) IL-10 and (iii) transforming growth factor beta. An impact of microenvironment on sHLA-G expression was found in B-NHL as shown by the in vitro effect of addition of normal monocytes. Finally, a functional effect of sHLA-G molecules purified from pathologic plasma was demonstrated by their strong capacity to inhibit T-cell proliferation at concentrations currently observed during these disorders. These results suggest that functional sHLA-G molecules are upregulated in lymphoproliferative disorders which can support their potential immunomodulatory role during this pathology.

Dates et versions

hal-00690715 , version 1 (24-04-2012)

Identifiants

Citer

Yasmine Sebti, Amélie Le Maux, Frédéric Gros, Sophie de Guibert, Céline Pangault, et al.. Expression of functional soluble human leucocyte antigen-G molecules in lymphoproliferative disorders.. British Journal of Haematology, 2007, 138 (2), pp.202-12. ⟨10.1111/j.1365-2141.2007.06647.x⟩. ⟨hal-00690715⟩
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