MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. - Archive ouverte HAL Access content directly
Journal Articles Nucleic Acids Research Year : 2010

MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks.

(1) , (2) , (1) , (2) , (3, 4) , (3, 5) , (1)
1
2
3
4
5

Abstract

High-throughput metabolomic experiments aim at identifying and ultimately quantifying all metabolites present in biological systems. The metabolites are interconnected through metabolic reactions, generally grouped into metabolic pathways. Classical metabolic maps provide a relational context to help interpret metabolomics experiments and a wide range of tools have been developed to help place metabolites within metabolic pathways. However, the representation of metabolites within separate disconnected pathways overlooks most of the connectivity of the metabolome. By definition, reference pathways cannot integrate novel pathways nor show relationships between metabolites that may be linked by common neighbours without being considered as joint members of a classical biochemical pathway. MetExplore is a web server that offers the possibility to link metabolites identified in untargeted metabolomics experiments within the context of genome-scale reconstructed metabolic networks. The analysis pipeline comprises mapping metabolomics data onto the specific metabolic network of an organism, then applying graph-based methods and advanced visualization tools to enhance data analysis. The MetExplore web server is freely accessible at http://metexplore.toulouse.inra.fr.

Keywords

Fichier principal
Vignette du fichier
2010_Cottret_Nucleic Acids Research_1.pdf (3.32 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-00690651 , version 1 (31-05-2020)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Ludovic Cottret, David Wildridge, Florence Vinson, Michael P Barrett, Hubert Charles, et al.. MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks.. Nucleic Acids Research, 2010, 38 (Web Server issue), pp.W132-7. ⟨10.1093/nar/gkq312⟩. ⟨hal-00690651⟩
385 View
58 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More