<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00688286</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-14T10:54:34+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Fish oil and heart health.</title>
            <author role="aut">
              <persName>
                <forename type="first">Joël</forename>
                <surname>de Leiris</surname>
              </persName>
              <idno type="halauthorid">253070-0</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>de Lorgeril</surname>
              </persName>
              <idno type="halauthorid">253071-0</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">François</forename>
                <surname>Boucher</surname>
              </persName>
              <email type="md5">0f6849f23840db580a3e916a7a878a15</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="idhal" notation="string">francois-boucher</idno>
              <idno type="idhal" notation="numeric">21413</idno>
              <idno type="halauthorid" notation="string">246032-21413</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5937-2014</idno>
              <idno type="IDREF">https://www.idref.fr/122132009</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-5937-2014</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6897-9321</idno>
              <affiliation ref="#struct-388395"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>François</forename>
                <surname>Boucher</surname>
              </persName>
              <email type="md5">8cba0d390a4f35f1d1780125dc6a6a43</email>
              <email type="domain">ujf-grenoble.fr.invalid</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2012-04-17 11:53:35</date>
              <date type="whenModified">2025-09-27 19:36:53</date>
              <date type="whenReleased">2012-04-17 11:53:35</date>
              <date type="whenProduced">2009-11</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="123946">
                <persName>
                  <forename>François</forename>
                  <surname>Boucher</surname>
                </persName>
                <email type="md5">8cba0d390a4f35f1d1780125dc6a6a43</email>
                <email type="domain">ujf-grenoble.fr.invalid</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00688286</idno>
            <idno type="halUri">https://hal.science/hal-00688286</idno>
            <idno type="halBibtex">deleiris:hal-00688286</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Cardiovascular Pharmacology&lt;/i&gt;, 2009, 54 (5), pp.378-384. &lt;a target="_blank" href="https://dx.doi.org/10.1097/FJC.0b013e3181af6c56"&gt;&amp;#x27E8;10.1097/FJC.0b013e3181af6c56&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Cardiovascular Pharmacology, 2009, 54 (5), pp.378-384. &amp;#x27E8;10.1097/FJC.0b013e3181af6c56&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-PRETA" corresp="TIMC-IMAG">PRETA : Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="commentary">Invited Review Article</note>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Fish oil and heart health.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Joël</forename>
                    <surname>de Leiris</surname>
                  </persName>
                  <idno type="halauthorid">253070-0</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>de Lorgeril</surname>
                  </persName>
                  <idno type="halauthorid">253071-0</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Boucher</surname>
                  </persName>
                  <email type="md5">0f6849f23840db580a3e916a7a878a15</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="idhal" notation="string">francois-boucher</idno>
                  <idno type="idhal" notation="numeric">21413</idno>
                  <idno type="halauthorid" notation="string">246032-21413</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-5937-2014</idno>
                  <idno type="IDREF">https://www.idref.fr/122132009</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-5937-2014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6897-9321</idno>
                  <affiliation ref="#struct-388395"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">15173</idno>
                <idno type="issn">0160-2446</idno>
                <title level="j">Journal of Cardiovascular Pharmacology</title>
                <imprint>
                  <publisher>Lippincott, Williams &amp; Wilkins</publisher>
                  <biblScope unit="volume">54</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">378-384</biblScope>
                  <date type="datePub">2009-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1097/FJC.0b013e3181af6c56</idno>
              <idno type="pubmed">19568180</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">n-3 fatty acids</term>
                <term xml:lang="en">fish oil</term>
                <term xml:lang="en">cardiovascular disease</term>
                <term xml:lang="en">cardiac arrhythmia</term>
                <term xml:lang="en">blood pressure</term>
                <term xml:lang="en">thrombosis</term>
              </keywords>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Blood Pressure</classCode>
              <classCode scheme="mesh">Cardiovascular Diseases</classCode>
              <classCode scheme="mesh">Dietary Fats</classCode>
              <classCode scheme="mesh">Dietary Supplements</classCode>
              <classCode scheme="mesh">Fish Oils</classCode>
              <classCode scheme="mesh">Fishes</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.phy">Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of cardiac arrhythmias have been identified as possible mechanisms. Moreover, n-3 fatty acids have anti-inflammatory effects, reduce blood pressure, and may also be antiatherogenic. Finally, high doses of n-3 fatty acids can lower elevated serum triglyceride levels. The n-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid) may be considered as a potential risk marker for coronary heart disease mortality, especially sudden cardiac death. The balance of n-6 to n-3 fatty acids is an important determinant in decreasing the risk for coronary heart disease, both in the primary and in the secondary prevention of coronary heart disease. Patients with known coronary heart disease should be recommended to consume n-3 fatty acid supplements at 1 g per day, without raising concerns for interactions with other medications or side effects. On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-388395" status="OLD">
          <orgName>Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée</orgName>
          <orgName type="acronym">TIMC-IMAG-PRETA</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr/preta</ref>
          </desc>
          <listRelation>
            <relation active="#struct-707" type="direct"/>
            <relation active="#struct-51016" type="indirect"/>
            <relation active="#struct-89889" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-707" status="OLD">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525</orgName>
          <orgName type="acronym">TIMC-IMAG</orgName>
          <date type="start">1993-01-01</date>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www-timc.imag.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation active="#struct-89889" type="direct"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-89889" status="OLD">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>