Secondary metabolites from Spirotropis longifolia (DC) Baill and their antifungal activity against human pathogenic fungi. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Phytochemistry Année : 2012

Secondary metabolites from Spirotropis longifolia (DC) Baill and their antifungal activity against human pathogenic fungi.

Charlie Basset
  • Fonction : Auteur
Alice M S Rodrigues
  • Fonction : Auteur
Maria R R Silva
  • Fonction : Auteur
Norberto P Lopes
  • Fonction : Auteur
Daniel Sabatier
  • Fonction : Auteur
Emile Fonty
  • Fonction : Auteur
Laila S Espindola
  • Fonction : Auteur
Didier Stien

Résumé

A phytochemical study of the ethyl acetate extract of the roots and adventitious roots of Spirotropis longifolia, a monodominant tree species of the Guianan rainforest, has allowed the isolation of three compounds: 2-hydroxy-8,9-methylenedioxy-2',2'-dimethylpyrano-[5',6':4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin A), 2-hydroxy-8,9-methylenedioxy-2',2'-dimethyl-3',4'-dihydropyrano-[5',6':4,3]-6a-prenyl-[6aS,11aS]-pterocarpan (spirotropin B), and 5,7-dihydroxy-6,8-diprenyl-2'''',2''''-dimethylpyrano[5'''',6'''': 3',4']-isoflavone (spirotropone). In addition, 10 known compounds, trans-oxyresveratrol, trans-resveratrol, piceatannol, daidzein, genistein, isoprunetin, lupeol, latifolol, gnetin D and gnetin E, were also isolated. These compounds were evaluated for their antifungal activity and their cytotoxicity, and their structures were established by 1D and 2D NMR, HRMS, CD and optical rotation measurements.

Domaines

Chimie organique

Dates et versions

hal-00678530 , version 1 (13-03-2012)

Identifiants

Citer

Charlie Basset, Alice M S Rodrigues, Véronique Eparvier, Maria R R Silva, Norberto P Lopes, et al.. Secondary metabolites from Spirotropis longifolia (DC) Baill and their antifungal activity against human pathogenic fungi.. Phytochemistry, 2012, 74, pp.166-72. ⟨10.1016/j.phytochem.2011.10.011⟩. ⟨hal-00678530⟩
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