CRTH2 and CD161 define a human IL-25 and IL-33−responsive type 2 innate lymphoid cell type
Résumé
Innate lymphoid cells (ILCs) are emerging as a family of effectors and regulators of innate immunity and tissue remodeling. Interleukin 22 (IL-22) and IL-17−producing ILCs, which depend on RORγt, express CD127 and CD161. We describe another Lin− CD127+CD161+ ILC population found in humans that express the chemoattractant receptor CRTH2. These cells responded in vitro to IL-2 plus IL-25 and IL-33 by producing IL-13. CRTH2+ ILCs were found in fetal and adult lung and gut. In fetal gut these cells expressed IL-13 but not IL-17 or IL-22. CRTH2+ ILCs were enriched in nasal polyps of chronic rhinosinusitis, a typical type 2 inflammatory disease. These data identify a unique human ILC type, which provides an innate source of TH2 cytokines.
Domaines
ImmunologieOrigine | Fichiers produits par l'(les) auteur(s) |
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