Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Medicine Année : 2012

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.

Résumé

The presentation pathways by which allogeneic peptides induce graft-versus-host disease (GVHD) are unclear. We developed a bone marrow transplant (BMT) system in mice whereby presentation of a processed recipient peptide within major histocompatibility complex (MHC) class II molecules could be spatially and temporally quantified. Whereas donor antigen presenting cells (APCs) could induce lethal acute GVHD via MHC class II, recipient APCs were 100-1,000 times more potent in this regard. After myeloablative irradiation, T cell activation and memory differentiation occurred in lymphoid organs independently of alloantigen. Unexpectedly, professional hematopoietic-derived recipient APCs within lymphoid organs had only a limited capacity to induce GVHD, and dendritic cells were not required. In contrast, nonhematopoietic recipient APCs within target organs induced universal GVHD mortality and promoted marked alloreactive donor T cell expansion within the gastrointestinal tract and inflammatory cytokine generation. These data challenge current paradigms, suggesting that experimental lethal acute GVHD can be induced by nonhematopoietic recipient APCs.

Domaines

Immunologie
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Dates et versions

hal-00672143 , version 1 (20-02-2012)

Identifiants

Citer

Motoko Koyama, Rachel D Kuns, Stuart D Olver, Neil C Raffelt, Yana A Wilson, et al.. Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.. Nature Medicine, 2012, 18 (1), pp.135-42. ⟨10.1038/nm.2597⟩. ⟨hal-00672143⟩

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