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Communication Dans Un Congrès Année : 2011

Investigation of TiO2 nanoparticles translocation through a Caco-2 monolayer

Résumé

Nanoparticles (NPs) are introduced in a growing number of commercial products, including food and beverage but their effects on gastrointestinal tract are poorly investigated. Here we focused on the translocation of TiO2 NPs through Caco-2 monolayers exposed to anatase and rutile NPs up to 24 h. Internalization was followed by transmission electronic microscopy and μ-XRF elemental mapping, coupled to XAS analysis of Ti atoms environment. This innovative technique is among the best techniques to get insights on NP fate after internalization. The originality of this project relies on the panel of microscopy techniques implemented to investigate digestive barrier translocation, bringing together biologists, chemists and physicists in a pluridisciplinary research program.

Dates et versions

hal-00659134 , version 1 (12-01-2012)

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Citer

E. Brun, M.-L. Jugan, Nathalie Herlin-Boime, D. Jaillard, B. Fayard, et al.. Investigation of TiO2 nanoparticles translocation through a Caco-2 monolayer. Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials, Nov 2010, Grenoble, France. pp.012048, ⟨10.1088/1742-6596/304/1/012048⟩. ⟨hal-00659134⟩
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