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Article Dans Une Revue ESAIM: Proceedings Année : 2012

Numerical simulation of the selection process of the ovarian follicles

Résumé

This paper presents the design and implementation of a numerical method to simulate a multiscale model describing the selection process in ovarian follicles. The PDE model consists in a quasi-linear hyperbolic system of large size, namely Nf × Nf , ruling the time evolution of the cell density functions of Nf follicles (in practice Nf is of the order of a few to twenty). These equations are weakly coupled through the sum of the first order moments of the density functions. The time- dependent equations make use of two structuring variables, age and maturity, which play the roles of space variables. The problem is naturally set over a compact domain of R2 . The formulation of the time-dependent controlled transport coefficients accounts for available biological knowledge on follicular cell kinetics. We introduce a dedicated numerical scheme that is amenable to parallelization, by taking advantage of the weak coupling. Numerical illustrations assess the relevance of the proposed method both in term of accuracy and HPC achievements.
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Dates et versions

hal-00656382 , version 1 (04-01-2012)

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Benjamin Aymard, Frédérique Clément, Frédéric Coquel, Marie Postel. Numerical simulation of the selection process of the ovarian follicles. ESAIM: Proceedings, 2012, 38, pp.99-117. ⟨10.1051/proc/201238006⟩. ⟨hal-00656382⟩
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