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Article Dans Une Revue Veterinary Microbiology Année : 2011

The extra-intestinal avian pathogenic strain BEN2908 invades avian and human epithelial cells and survives intracellularly

Résumé

Extra-intestinal pathogenic (ExPEC) are responsible for a wide range of diseases in humans and animals. By using invasion assays and transmission electron microscopy, we showed that BEN2908, an ExPEC strain of avian origin (also termed APEC for Avian Pathogenic ), is able to usurp cellular endocytic pathways to invade A549 human type II pneumocytes and LMH avian hepathocytes where it is able to survive over several days. Although type 1 fimbriae are the major adhesin of BEN2908, proportions of adherent fimbriated or afimbriated bacteria that entered cells were comparable. Internalization of BEN2908 into human pneumocytes reinforces previous studies indicating that APEC strains could represent a zoonotic risk.
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hal-00654948 , version 1 (24-12-2011)

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Nathalie Katy Chanteloup, Gaëlle Porcheron, Bernadette Delaleu, Pierre Germon, Catherine Schouler, et al.. The extra-intestinal avian pathogenic strain BEN2908 invades avian and human epithelial cells and survives intracellularly. Veterinary Microbiology, 2011, 147 (3-4), pp.435-439. ⟨10.1016/j.vetmic.2010.07.013⟩. ⟨hal-00654948⟩
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