<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00640764</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T09:03:36+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">DNA double-strand breaks induced by mammographic screening procedures in human mammary epithelial cells</title>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Colin</surname>
              </persName>
              <idno type="halauthorid">146573-0</idno>
              <affiliation ref="#struct-93083"/>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Clément</forename>
                <surname>Devic</surname>
              </persName>
              <idno type="halauthorid">221760-0</idno>
              <affiliation ref="#struct-86972"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Noel</surname>
              </persName>
              <idno type="halauthorid">169404-0</idno>
              <affiliation ref="#struct-101696"/>
              <affiliation ref="#struct-1001"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Muriel</forename>
                <surname>Rabilloud</surname>
              </persName>
              <email type="md5">947bdbfed1f2c42bd7b7f737486103d9</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="string">muriel-rabilloud-ferrand</idno>
              <idno type="idhal" notation="numeric">181462</idno>
              <idno type="halauthorid" notation="string">5018-181462</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1324-0356</idno>
              <idno type="IDREF">https://www.idref.fr/170401731</idno>
              <affiliation ref="#struct-353860"/>
              <affiliation ref="#struct-543539"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Thérèse</forename>
                <surname>Zabot</surname>
              </persName>
              <idno type="halauthorid">457250-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sylvie</forename>
                <surname>Pinet-Isaac</surname>
              </persName>
              <idno type="halauthorid">604442-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophie</forename>
                <surname>Giraud</surname>
              </persName>
              <email type="md5">5e7f5f07b5a474c4cb038a5ebc52f44f</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="numeric">1359982</idno>
              <idno type="halauthorid" notation="string">34051-1359982</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1243-3084</idno>
              <affiliation ref="#struct-167950"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <surname>Riche</surname>
              </persName>
              <email type="md5">274083c0c4de13be55baf5546b7b029c</email>
              <email type="domain">chu-lyon.fr</email>
              <idno type="idhal" notation="string">benjamin-riche</idno>
              <idno type="idhal" notation="numeric">745173</idno>
              <idno type="halauthorid" notation="string">385906-745173</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6167-8171</idno>
              <affiliation ref="#struct-543539"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre-Jean</forename>
                <surname>Valette</surname>
              </persName>
              <idno type="halauthorid">448911-0</idno>
              <affiliation ref="#struct-353860"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Rodriguez-Lafrasse</surname>
              </persName>
              <email type="md5">9b087e46a997ad389d0c1f53ca90ca0b</email>
              <email type="domain">adm.univ-lyon1.fr</email>
              <idno type="idhal" notation="numeric">854059</idno>
              <idno type="halauthorid" notation="string">227490-854059</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9670-1853</idno>
              <idno type="IDREF">https://www.idref.fr/134232429</idno>
              <idno type="VIAF">https://viaf.org/viaf/54250456</idno>
              <idno type="ISNI">http://isni.org/isni/0000000000350968</idno>
              <affiliation ref="#struct-93083"/>
              <affiliation ref="#struct-353860"/>
              <affiliation ref="#struct-194495"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Foray</surname>
              </persName>
              <email type="md5">4ed7449db99b8ed6e10f483330a7172e</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">nicolasforayinsermfr</idno>
              <idno type="idhal" notation="numeric">749600</idno>
              <idno type="halauthorid" notation="string">221763-749600</idno>
              <idno type="IDREF">https://www.idref.fr/08378988X</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1282-1303</idno>
              <affiliation ref="#struct-86972"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Marie Ange</forename>
                <surname>D'Hallewin</surname>
              </persName>
              <email type="md5">979311654740d10b0bdaf17185c53d79</email>
              <email type="domain">nancy.fnclcc.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2011-11-14 11:34:28</date>
              <date type="whenModified">2025-11-04 12:02:24</date>
              <date type="whenReleased">2011-11-14 11:34:28</date>
              <date type="whenProduced">2011-11</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="113233">
                <persName>
                  <forename>Marie Ange</forename>
                  <surname>D'Hallewin</surname>
                </persName>
                <email type="md5">979311654740d10b0bdaf17185c53d79</email>
                <email type="domain">nancy.fnclcc.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00640764</idno>
            <idno type="halUri">https://hal.science/hal-00640764</idno>
            <idno type="halBibtex">colin:hal-00640764</idno>
            <idno type="halRefHtml">&lt;i&gt;International Journal of Radiation Biology&lt;/i&gt;, 2011, 87 (11), pp.1103-1112. &lt;a target="_blank" href="https://dx.doi.org/10.3109/09553002.2011.608410"&gt;&amp;#x27E8;10.3109/09553002.2011.608410&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">International Journal of Radiation Biology, 2011, 87 (11), pp.1103-1112. &amp;#x27E8;10.3109/09553002.2011.608410&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="INPL">Institut National Polytechnique de Lorraine</idno>
            <idno type="stamp" n="CRAN">Centre de Recherche en Automatique de Nancy</idno>
            <idno type="stamp" n="CRAN-IPS" corresp="CRAN">CRAN - Ingénierie pour la Santé</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="LBBE" corresp="UNIV-LYON1">Laboratoire de biométrie et biologie évolutive </idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
            <idno type="stamp" n="AM2I-UL">Pôle scientifique Automatique, Mathématiques, Informatique et leurs Intéractions de l'Université de Lorraine</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">DNA double-strand breaks induced by mammographic screening procedures in human mammary epithelial cells</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Colin</surname>
                  </persName>
                  <idno type="halauthorid">146573-0</idno>
                  <affiliation ref="#struct-93083"/>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Clément</forename>
                    <surname>Devic</surname>
                  </persName>
                  <idno type="halauthorid">221760-0</idno>
                  <affiliation ref="#struct-86972"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Noel</surname>
                  </persName>
                  <idno type="halauthorid">169404-0</idno>
                  <affiliation ref="#struct-101696"/>
                  <affiliation ref="#struct-1001"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Muriel</forename>
                    <surname>Rabilloud</surname>
                  </persName>
                  <email type="md5">947bdbfed1f2c42bd7b7f737486103d9</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="string">muriel-rabilloud-ferrand</idno>
                  <idno type="idhal" notation="numeric">181462</idno>
                  <idno type="halauthorid" notation="string">5018-181462</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1324-0356</idno>
                  <idno type="IDREF">https://www.idref.fr/170401731</idno>
                  <affiliation ref="#struct-353860"/>
                  <affiliation ref="#struct-543539"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Thérèse</forename>
                    <surname>Zabot</surname>
                  </persName>
                  <idno type="halauthorid">457250-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sylvie</forename>
                    <surname>Pinet-Isaac</surname>
                  </persName>
                  <idno type="halauthorid">604442-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophie</forename>
                    <surname>Giraud</surname>
                  </persName>
                  <email type="md5">5e7f5f07b5a474c4cb038a5ebc52f44f</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="numeric">1359982</idno>
                  <idno type="halauthorid" notation="string">34051-1359982</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1243-3084</idno>
                  <affiliation ref="#struct-167950"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <surname>Riche</surname>
                  </persName>
                  <email type="md5">274083c0c4de13be55baf5546b7b029c</email>
                  <email type="domain">chu-lyon.fr</email>
                  <idno type="idhal" notation="string">benjamin-riche</idno>
                  <idno type="idhal" notation="numeric">745173</idno>
                  <idno type="halauthorid" notation="string">385906-745173</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6167-8171</idno>
                  <affiliation ref="#struct-543539"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre-Jean</forename>
                    <surname>Valette</surname>
                  </persName>
                  <idno type="halauthorid">448911-0</idno>
                  <affiliation ref="#struct-353860"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Rodriguez-Lafrasse</surname>
                  </persName>
                  <email type="md5">9b087e46a997ad389d0c1f53ca90ca0b</email>
                  <email type="domain">adm.univ-lyon1.fr</email>
                  <idno type="idhal" notation="numeric">854059</idno>
                  <idno type="halauthorid" notation="string">227490-854059</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9670-1853</idno>
                  <idno type="IDREF">https://www.idref.fr/134232429</idno>
                  <idno type="VIAF">https://viaf.org/viaf/54250456</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000000350968</idno>
                  <affiliation ref="#struct-93083"/>
                  <affiliation ref="#struct-353860"/>
                  <affiliation ref="#struct-194495"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Foray</surname>
                  </persName>
                  <email type="md5">4ed7449db99b8ed6e10f483330a7172e</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">nicolasforayinsermfr</idno>
                  <idno type="idhal" notation="numeric">749600</idno>
                  <idno type="halauthorid" notation="string">221763-749600</idno>
                  <idno type="IDREF">https://www.idref.fr/08378988X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1282-1303</idno>
                  <affiliation ref="#struct-86972"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">IPS</idno>
                <idno type="halJournalId" status="VALID">14669</idno>
                <idno type="issn">0955-3002</idno>
                <idno type="eissn">1362-3095</idno>
                <title level="j">International Journal of Radiation Biology</title>
                <imprint>
                  <publisher>Taylor and Francis</publisher>
                  <biblScope unit="volume">87</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">1103-1112</biblScope>
                  <date type="datePub">2011-11</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3109/09553002.2011.608410</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">DNA double-strand break</term>
                <term xml:lang="en">DNA double-strand break Mammography</term>
                <term xml:lang="en">low-dose radiation effect</term>
                <term xml:lang="en">ionising radiation</term>
                <term xml:lang="en">DNA damage</term>
                <term xml:lang="en">Mammography</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.bbm.bp">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Purpose: To assess in vitro mammographic radiation-induced DNA damage in mammary epithelial cells from 30 patients with low (LR) or high (HR) family risk of breast cancer. Materials and methods: Spontaneous and radiation-induced DNA double-strand breaks (DSB) were quantifi ed by using immunofl uorescence of the phosphorylated H2AX histone ( γ H2AX) in diff erent conditions of mammography irradiation (2, 4, 2 2 mGy). Results: HR patients showed signifi cantly more spontaneous γ H2AX foci than LR patients ( p 0.014). A signifi cant dose-eff ect was observed, with an exacerbation in HR patients ( p 0.01). The dose repetition (2 2 mGy) provided more induced and more unrepaired DSB than 2 mGy and 4 mGy, and was exacerbated in HR ( p 0.006). Conclusions: This study highlights the existence of DSB induced by mammography and revealed by γ H2AX assay with two major radiobiological eff ects occurring: A low-dose eff ect, and a LOw and Repeated Dose (LORD) eff ect. All these eff ects were exacerbated in HR patients. These fi ndings may lead us to reevaluate the number of views performed in screening using a single view (oblique) in women whose mammographic benefi t has not properly been proved such as HR patients.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-93083" status="INCOMING">
          <orgName>Laboratoire de Radiobiologie Cellulaire et Moléculaire</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-322939" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-86972" status="OLD">
          <orgName>Grenoble Institut des Neurosciences</orgName>
          <orgName type="acronym">GIN</orgName>
          <date type="start">2007-01-01</date>
          <date type="end">2013-12-31</date>
          <desc>
            <address>
              <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-51016" type="direct"/>
            <relation name="U836" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-101696" status="OLD">
          <orgName>Centre Alexis Vautrin</orgName>
          <orgName type="acronym">CAV</orgName>
          <date type="start">1976</date>
          <date type="end">2013-03</date>
          <desc>
            <address>
              <addrLine>6 avenue de Bourgogne, 54519 Vandoeuvre les Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.alexisvautrin.fr/cav/jsp/site/Portal.jsp</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1001" status="OLD">
          <orgName>Centre de Recherche en Automatique de Nancy</orgName>
          <orgName type="acronym">CRAN</orgName>
          <date type="start">2001-01-01</date>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>Université Henri Poincaré, 2 avenue de la forêt de Haye, 54516 Vandoeuvre les Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cran.uhp-nancy.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300291" type="direct"/>
            <relation active="#struct-300293" type="direct"/>
            <relation name="UMR7039" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-543539" status="OLD">
          <orgName>Biostatistiques santé [LBBE]</orgName>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>LBBE43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lbbe.univ-lyon1.fr/-Equipe-Biostatistique-sante-.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-543491" type="direct"/>
            <relation active="#struct-10025" type="indirect"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5558" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-167950" status="VALID">
          <orgName>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents</orgName>
          <desc>
            <address>
              <addrLine>28 Rue Laennec, 69008 Lyon</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-20549" type="direct"/>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-322939" status="INCOMING">
          <orgName>Faculté de Médecine Lyon-Sud</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-51016" status="OLD">
          <idno type="IdRef">026404796</idno>
          <idno type="ROR">https://ror.org/02aj0kh94</idno>
          <orgName>Université Joseph Fourier - Grenoble 1</orgName>
          <orgName type="acronym">UJF</orgName>
          <date type="end">2015-12-31</date>
          <desc>
            <address>
              <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ujf-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300291" status="OLD">
          <orgName>Université Henri Poincaré - Nancy 1</orgName>
          <orgName type="acronym">UHP</orgName>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <addrLine>24-30 rue Lionnois, BP 60120, 54 003 NANCY cedex, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300293" status="OLD">
          <orgName>Institut National Polytechnique de Lorraine</orgName>
          <orgName type="acronym">INPL</orgName>
          <date type="end">2011-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-543491" status="OLD">
          <orgName>Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]</orgName>
          <date type="end">2020-12-31</date>
          <desc>
            <address>
              <addrLine>LBBE43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://lbbe.univ-lyon1.fr/-Departement-Biostatistiques-et-Modelisation-pour-la-Sante-et-l-environnement-.html</ref>
          </desc>
          <listRelation>
            <relation active="#struct-10025" type="direct"/>
            <relation active="#struct-194495" type="indirect"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5558" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-10025" status="VALID">
          <idno type="IdRef">15069671X</idno>
          <idno type="ISNI">0000000403863493</idno>
          <idno type="RNSR">199411998X</idno>
          <idno type="ROR">https://ror.org/03skt0t88</idno>
          <orgName>Laboratoire de Biométrie et Biologie Evolutive - UMR 5558</orgName>
          <orgName type="acronym">LBBE</orgName>
          <date type="start">1995-01-01</date>
          <desc>
            <address>
              <addrLine>43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://lbbe.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5558" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-20549" status="VALID">
          <idno type="ROR">https://ror.org/01cmnjq37</idno>
          <orgName>Centre Léon Bérard [Lyon]</orgName>
          <desc>
            <address>
              <addrLine>28, rue Laennec 69373 LYON Cedex 08</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centreleonberard.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>