<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00637405</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-06T22:57:40+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2.</title>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Hegde</surname>
              </persName>
              <idno type="halauthorid">593904-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Maddur</surname>
              </persName>
              <idno type="halauthorid">593905-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Friboulet</surname>
              </persName>
              <email type="md5">56bdc53fc77e1263e1919ac1aff8284c</email>
              <email type="domain">utc.fr</email>
              <idno type="idhal" notation="numeric">833526</idno>
              <idno type="halauthorid" notation="string">143395-833526</idno>
              <idno type="IDREF">https://www.idref.fr/059919558</idno>
              <affiliation ref="#struct-801"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Bayry</surname>
              </persName>
              <email type="md5">a850f55ac182f3987918a33d0dbb7471</email>
              <email type="domain">crc.jussieu.fr</email>
              <idno type="idhal" notation="numeric">766432</idno>
              <idno type="halauthorid" notation="string">154426-766432</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0498-9808</idno>
              <idno type="IDREF">https://www.idref.fr/077311019</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.V.</forename>
                <surname>Kaveri</surname>
              </persName>
              <email type="md5">848968a501c9956bc1f94c55fc8fdb25</email>
              <email type="domain">crc.jussieu.fr</email>
              <idno type="idhal" notation="string">srini-kaveri</idno>
              <idno type="idhal" notation="numeric">1178998</idno>
              <idno type="halauthorid" notation="string">128219-1178998</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0837-4053</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Chantal</forename>
                <surname>David</surname>
              </persName>
              <email type="md5">d1aef102cf7be1072fcc1629b947b521</email>
              <email type="domain">utc.fr.invalid</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2011-11-01 20:27:00</date>
              <date type="whenModified">2025-10-02 15:52:02</date>
              <date type="whenReleased">2011-11-01 20:27:00</date>
              <date type="whenProduced">2011</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196571"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="107472">
                <persName>
                  <forename>Chantal</forename>
                  <surname>David</surname>
                </persName>
                <email type="md5">d1aef102cf7be1072fcc1629b947b521</email>
                <email type="domain">utc.fr.invalid</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00637405</idno>
            <idno type="halUri">https://hal.science/hal-00637405</idno>
            <idno type="halBibtex">hegde:hal-00637405</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS ONE&lt;/i&gt;, 2011, 6 (10), pp.e26312. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.pone.0026312"&gt;&amp;#x27E8;10.1371/journal.pone.0026312&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS ONE, 2011, 6 (10), pp.e26312. &amp;#x27E8;10.1371/journal.pone.0026312&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-COMPIEGNE">Université de Technologie de Compiègne</idno>
            <idno type="stamp" n="GEC" corresp="UNIV-COMPIEGNE">Laboratoire GEC - Génie Enzymatique et Cellulaire</idno>
            <idno type="stamp" n="GEC-UTC" corresp="GEC">Génie Enzymatique et Cellulaire UTC</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Hegde</surname>
                  </persName>
                  <idno type="halauthorid">593904-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Maddur</surname>
                  </persName>
                  <idno type="halauthorid">593905-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Friboulet</surname>
                  </persName>
                  <email type="md5">56bdc53fc77e1263e1919ac1aff8284c</email>
                  <email type="domain">utc.fr</email>
                  <idno type="idhal" notation="numeric">833526</idno>
                  <idno type="halauthorid" notation="string">143395-833526</idno>
                  <idno type="IDREF">https://www.idref.fr/059919558</idno>
                  <affiliation ref="#struct-801"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Bayry</surname>
                  </persName>
                  <email type="md5">a850f55ac182f3987918a33d0dbb7471</email>
                  <email type="domain">crc.jussieu.fr</email>
                  <idno type="idhal" notation="numeric">766432</idno>
                  <idno type="halauthorid" notation="string">154426-766432</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0498-9808</idno>
                  <idno type="IDREF">https://www.idref.fr/077311019</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.V.</forename>
                    <surname>Kaveri</surname>
                  </persName>
                  <email type="md5">848968a501c9956bc1f94c55fc8fdb25</email>
                  <email type="domain">crc.jussieu.fr</email>
                  <idno type="idhal" notation="string">srini-kaveri</idno>
                  <idno type="idhal" notation="numeric">1178998</idno>
                  <idno type="halauthorid" notation="string">128219-1178998</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0837-4053</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">28700</idno>
                <idno type="issn">1932-6203</idno>
                <idno type="eissn">1932-6203</idno>
                <title level="j">PLoS ONE</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">6</biblScope>
                  <biblScope unit="issue">10</biblScope>
                  <biblScope unit="pp">e26312</biblScope>
                  <date type="datePub">2011</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pone.0026312</idno>
              <idno type="pubmedcentral">PMC3196571</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="spi.other">Engineering Sciences [physics]/Other</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Viscum album (VA) preparations are extensively used as complementary therapy in cancer and are shown to exert anti-tumor activities which involve the cytotoxic properties, induction of apoptosis, inhibition of angiogenesis and several other immunomodulatory mechanisms. In addition to their application in cancer therapy, VA preparations have also been successfully utilized in the treatment of several inflammatory pathologies. Owing to the intricate association of inflammation and cancer and in view of the fact that several anti-tumor phytotherapeutics also exert a potent anti-inflammatory effect, we hypothesized that VA exerts an anti-inflammatory effect that is responsible for its therapeutic benefit. Since, inflammatory cytokine-induced cyclo-oxygenase-2 (COX-2) and prostaglandin E2 (PGE2) play a critical role in the pathogenesis of inflammatory diseases, we investigated the anti-inflammatory effect of VA on regulation of cyclo-oxygenase expression and PGE2 biosynthesis by using human lung adenocarcinoma cells (A549 cells) as a model. A549 cells were stimulated with IL-1β and treated with VA preparation (VA Qu Spez) for 18 hours. PGE2 was analysed in the culture supernatants by enzyme immunoassay. Expression of COX-2 and COX-1 proteins was analyzed by immunoblotting and the expression of COX-2 mRNA was assessed by semi-quantitative RT-PCR. We found that VA Qu Spez inhibit the secretion of IL-1β-induced PGE2 in a dose-dependent manner. Further, we also show that this inhibitory action was associated with a reduced expression of COX-2 without modulating the COX-1 expression. Together these results demonstrate a novel anti-inflammatory mechanism of action of VA preparations wherein VA exerts an anti-inflammatory effect by inhibiting cytokine-induced PGE2 via selective inhibition of COX-2.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-801" status="VALID">
          <idno type="ROR">https://ror.org/001tmq304</idno>
          <orgName>Génie Enzymatique et Cellulaire</orgName>
          <orgName type="acronym">GEC</orgName>
          <date type="start">2000-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Technologie de Compiègne - Centre de Recherche de Royallieu - rue du Docteur Schweitzer- CS 60319 - 60203 COMPIEGNE Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.utc.fr/umr6022</ref>
          </desc>
          <listRelation>
            <relation name="UMR6022" active="#struct-93027" type="direct"/>
            <relation name="UMR6022" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-93027" status="VALID">
          <idno type="ROR">https://ror.org/04y5kwa70</idno>
          <orgName>Université de Technologie de Compiègne</orgName>
          <orgName type="acronym">UTC</orgName>
          <desc>
            <address>
              <addrLine>Université de Technologie de Compiègne - rue du Docteur Schweitzer- CS 60319 - 60203 Compiègne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.utc.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>