<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00637076</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-01T22:40:59+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Risk factors for, and clinical relevance of, faecal extended-spectrum β-lactamase producing (ESBL-EC) carriage in neutropenic patients with haematological malignancies</title>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Arnan</surname>
              </persName>
              <idno type="halauthorid">593722-0</idno>
              <affiliation ref="#struct-172554"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">C.</forename>
                <surname>Gudiol</surname>
              </persName>
              <email type="md5">dc5e4361c60570da74133aeaa208b546</email>
              <email type="domain">iconcologia.net</email>
              <idno type="idhal" notation="numeric">913021</idno>
              <idno type="halauthorid" notation="string">593723-913021</idno>
              <affiliation ref="#struct-172555"/>
              <affiliation ref="#struct-172556"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">L.</forename>
                <surname>Calatayud</surname>
              </persName>
              <idno type="halauthorid">593724-0</idno>
              <affiliation ref="#struct-172557"/>
              <affiliation ref="#struct-172558"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Liñares</surname>
              </persName>
              <idno type="halauthorid">593725-0</idno>
              <affiliation ref="#struct-172558"/>
              <affiliation ref="#struct-172557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M. Á.</forename>
                <surname>Dominguez</surname>
              </persName>
              <idno type="halauthorid">593726-0</idno>
              <affiliation ref="#struct-172557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M.</forename>
                <surname>Batlle</surname>
              </persName>
              <idno type="halauthorid">593727-0</idno>
              <affiliation ref="#struct-172561"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J. M.</forename>
                <surname>Ribera</surname>
              </persName>
              <idno type="halauthorid">593728-0</idno>
              <affiliation ref="#struct-172561"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Carratalà</surname>
              </persName>
              <idno type="halauthorid">566432-0</idno>
              <affiliation ref="#struct-172556"/>
              <affiliation ref="#struct-172555"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">F.</forename>
                <surname>Gudiol</surname>
              </persName>
              <idno type="halauthorid">566435-0</idno>
              <affiliation ref="#struct-172556"/>
              <affiliation ref="#struct-172555"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Hal</forename>
                <surname>Peer</surname>
              </persName>
              <email type="md5">8d58fc1b670b8074dd83e4a4c93d5914</email>
              <email type="domain">inria.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2011-10-30 02:50:14</date>
              <date type="whenWritten">2010-07-01</date>
              <date type="whenModified">2024-11-22 15:44:02</date>
              <date type="whenReleased">2011-10-30 02:50:14</date>
              <date type="whenProduced">2010-10-30</date>
              <date type="whenEndEmbargoed">2011-10-30</date>
              <ref type="file" target="https://hal.science/hal-00637076v1/document">
                <date notBefore="2011-10-30"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-00637076v1/file/PEER_stage2_10.1007%252Fs10096-010-1093-x.pdf" id="file-637076-345661">
                <date notBefore="2011-10-30"/>
              </ref>
              <ref type="externalLink" target="https://api.istex.fr/document/D0E8A0C101A4AC2C4DF845654EC1717AA85669FA/fulltext/pdf?sid=hal"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="148147">
                <persName>
                  <forename>Hal</forename>
                  <surname>Peer</surname>
                </persName>
                <email type="md5">8d58fc1b670b8074dd83e4a4c93d5914</email>
                <email type="domain">inria.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00637076</idno>
            <idno type="halUri">https://hal.science/hal-00637076</idno>
            <idno type="halBibtex">arnan:hal-00637076</idno>
            <idno type="halRefHtml">&lt;i&gt;European Journal of Clinical Microbiology and Infectious Diseases&lt;/i&gt;, 2010, pp.355-360. &lt;a target="_blank" href="https://dx.doi.org/10.1007/s10096-010-1093-x"&gt;&amp;#x27E8;10.1007/s10096-010-1093-x&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">European Journal of Clinical Microbiology and Infectious Diseases, 2010, pp.355-360. &amp;#x27E8;10.1007/s10096-010-1093-x&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-637076-345661"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="PEER">PEER Publishing and the Ecology of European Research</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Risk factors for, and clinical relevance of, faecal extended-spectrum β-lactamase producing (ESBL-EC) carriage in neutropenic patients with haematological malignancies</title>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Arnan</surname>
                  </persName>
                  <idno type="halauthorid">593722-0</idno>
                  <affiliation ref="#struct-172554"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Gudiol</surname>
                  </persName>
                  <email type="md5">dc5e4361c60570da74133aeaa208b546</email>
                  <email type="domain">iconcologia.net</email>
                  <idno type="idhal" notation="numeric">913021</idno>
                  <idno type="halauthorid" notation="string">593723-913021</idno>
                  <affiliation ref="#struct-172555"/>
                  <affiliation ref="#struct-172556"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">L.</forename>
                    <surname>Calatayud</surname>
                  </persName>
                  <idno type="halauthorid">593724-0</idno>
                  <affiliation ref="#struct-172557"/>
                  <affiliation ref="#struct-172558"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Liñares</surname>
                  </persName>
                  <idno type="halauthorid">593725-0</idno>
                  <affiliation ref="#struct-172558"/>
                  <affiliation ref="#struct-172557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M. Á.</forename>
                    <surname>Dominguez</surname>
                  </persName>
                  <idno type="halauthorid">593726-0</idno>
                  <affiliation ref="#struct-172557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M.</forename>
                    <surname>Batlle</surname>
                  </persName>
                  <idno type="halauthorid">593727-0</idno>
                  <affiliation ref="#struct-172561"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J. M.</forename>
                    <surname>Ribera</surname>
                  </persName>
                  <idno type="halauthorid">593728-0</idno>
                  <affiliation ref="#struct-172561"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Carratalà</surname>
                  </persName>
                  <idno type="halauthorid">566432-0</idno>
                  <affiliation ref="#struct-172556"/>
                  <affiliation ref="#struct-172555"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">F.</forename>
                    <surname>Gudiol</surname>
                  </persName>
                  <idno type="halauthorid">566435-0</idno>
                  <affiliation ref="#struct-172556"/>
                  <affiliation ref="#struct-172555"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13022</idno>
                <idno type="issn">0934-9723</idno>
                <idno type="eissn">1435-4373</idno>
                <title level="j">European Journal of Clinical Microbiology and Infectious Diseases</title>
                <imprint>
                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="pp">355-360</biblScope>
                  <date type="datePub">2010-10-30</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s10096-010-1093-x</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="fr">Life Sciences</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The purpose of this study was to assess the risk factors for, and the clinical relevance of, faecal carriage by extended-spectrum β-lactamase producing (ESBL-EC) in neutropenic cancer patients (NCP). An observational prospective multicentre cohort study was conducted over 2 years at two teaching hospitals. Patients with acute leukaemia or undergoing stem cell transplantation were included during neutropenia episodes. Rectal swabs were obtained at hospital admission and weekly thereafter until discharge or death. ESBL-EC colonized episodes were compared with non-colonized episodes. ESBL-EC strains were studied by PCR and isoelectric focusing, and molecular typing was performed by pulsed field gel electrophoresis (PFGE). Among 217 episodes of neutropenia, the prevalence of ESBL-EC faecal carriage was 29% (14% at hospital admission). Multivariate analysis identified previous antibiotics as the only independent risk factor for ESBL-EC faecal colonization (OR 5.38; 95% CI 2.79-10.39). Analysis of ESBL-EC isolates revealed a polyclonal distribution with CTX-M predominance (81.3%). bacteraemia was mainly caused by non-ESBL producing strains and its rate was similar in both groups (13% vs. 11%). We found no association between ESBL-EC carriage and an increased risk of ESBL-EC bacteremia or a negative influence on other clinical outcomes, including length of hospitalisation, early and overall mortality rates. ESBL-EC faecal colonization is frequent in NCP but difficult to identify by epidemiological or clinical features on presentation. Prior antibiotic therapy is the major associated risk factor. In this setting colonization does not appear to have a significant clinical relevance. Thus, routine testing for ESBL-EC faecal carriage does not seem to be beneficial.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-172554" status="INCOMING">
          <orgName>Hematology Department</orgName>
          <desc>
            <address>
              <addrLine>Barcelona</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-343659" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-172555" status="INCOMING">
          <orgName>Infectious Disease Department</orgName>
          <desc>
            <address>
              <addrLine>Feixa Llarga s/n;08907;Barcelona</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-341374" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-172556" status="INCOMING">
          <orgName>REIPI (Spanish Network for Research in Infectious Diseases)</orgName>
          <desc>
            <address>
              <addrLine>Madrid</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-308343" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-172557" status="INCOMING">
          <orgName>Microbiology Department</orgName>
          <desc>
            <address>
              <addrLine>Barcelona</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-343661" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-172558" status="INCOMING">
          <orgName>Ciber de Enfermedades Respiratorias, ISCIII</orgName>
          <desc>
            <address>
              <addrLine>Madrid</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-343662" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-172561" status="INCOMING">
          <orgName>Haematology Department</orgName>
          <desc>
            <address>
              <addrLine>Badalona, Barcelona</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-310167" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-343659" status="INCOMING">
          <orgName>Hospital Duran i Reynals, l'Hospitalet de Llobregat</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341374" status="VALID">
          <orgName>Bellvitge University Hospital =  Bellvitge Hospital Universitari</orgName>
          <date type="start">1972-01-01</date>
          <desc>
            <address>
              <addrLine>Bellvitge</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://bellvitgehospital.cat</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-308343" status="VALID">
          <idno type="ROR">https://ror.org/00ca2c886</idno>
          <orgName>Instituto de Salud Carlos III [Madrid]</orgName>
          <orgName type="acronym">ISCIII</orgName>
          <desc>
            <address>
              <addrLine>Carretera de Majadahonda - Pozuelo, 28220 Majadahonda, Madrid, Espagne</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.isciii.es/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-343661" status="INCOMING">
          <orgName>Hospital Universitari de Bellvitge, l'Hospitalet de Llobregat</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-343662" status="INCOMING">
          <orgName>Ciber de Enfermedades Respiratorias, ISCIII</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-310167" status="INCOMING">
          <orgName>Hospital Germans Trias I Pujol</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>