Micrometric molecular histology of lipids by mass spectrometry imaging. - Archive ouverte HAL
Article Dans Une Revue Current Opinion in Chemical Biology Année : 2011

Micrometric molecular histology of lipids by mass spectrometry imaging.

Résumé

Time-Of-Flight Secondary Ion Mass Spectrometry is compared to other mass spectrometry imaging techniques, and recent improvements of the experimental methods, driven by biological and biomedical applications, are described and discussed. This review shows that this method that can be considered as a micrometric molecular histology is particularly efficient for obtaining images of various lipid species at the surface of a tissue sample, without sample preparation, and with a routine spatial resolution of 1μm or less.

Domaines

Chimie organique

Dates et versions

hal-00634156 , version 1 (20-10-2011)

Identifiants

Citer

David Touboul, Olivier Laprévote, Alain Brunelle. Micrometric molecular histology of lipids by mass spectrometry imaging.. Current Opinion in Chemical Biology, 2011, 15 (5), pp.725-732. ⟨10.1016/j.cbpa.2011.04.017⟩. ⟨hal-00634156⟩
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