High frequencies of short alleles of NOS1 (CA)n polymorphism in beta(0)39 carriers from Corsica Island (France). - Archive ouverte HAL Access content directly
Journal Articles Experimental and Molecular Pathology Year : 2009

High frequencies of short alleles of NOS1 (CA)n polymorphism in beta(0)39 carriers from Corsica Island (France).

I. S. Piras
  • Function : Author
A. Melis
M. C. de Cian
  • Function : Author
C. M. Calò
  • Function : Author
G. Vona
  • Function : Author

Abstract

In this work we investigated about the presence of a correlation between a (CA)n repeat located in exon 29 of NOS1 gene and the beta-thalassemia trait in Corsica Island (France). We genotyped a sample of individuals with beta-thalassemia minor (N=110) and an ethnically matched control (N=113) from Balagna, a region of Corsica Island (France). Results highlighted the high frequencies of allele with 16 and 17 repeats in the thalassemic sample. From these results we suggest, that high frequencies of alleles with 16 and 17 repeats, could be a consequence of past malarial endemicity.

Dates and versions

hal-00628442 , version 1 (03-10-2011)

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I. S. Piras, A. Falchi, A. Melis, M. C. de Cian, C. M. Calò, et al.. High frequencies of short alleles of NOS1 (CA)n polymorphism in beta(0)39 carriers from Corsica Island (France).. Experimental and Molecular Pathology, 2009, 86 (2), pp.136-7. ⟨10.1016/j.yexmp.2008.11.007⟩. ⟨hal-00628442⟩
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