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Article Dans Une Revue Environmental Pollution Année : 2011

Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha

Résumé

Bioaccumulation and effects of the contraceptive hormone levonorgestrel were examined in the nontarget organism Dreissena polymorpha. Molecular biomarkers of biotransformation, elimination, antioxidant defence and protein damage were analyzed after exposure to increasing concentrations of levonorgestrel in a flow-through system. The lowest concentration (0.312 mg L-1) was 100-fold bioconcentrated within four days. A decrease of the bioconcentration factor was observed within one week for the highest test concentrations (3.12 and 6.24 mg L-1) suggesting enhanced excretory processes. The immediate mRNA up-regulation of pi class glutathione S-transferase proved that phase II biotransformation processes were induced. Disturbance of fundamental cell functions was assumed since the aryl hydrocarbon receptor has been permanently down-regulated. mRNA up-regulation of P-glycoprotein, superoxide dismutase and metallothioneine suggested enhanced elimination processes and ongoing oxidative stress. mRNA up-regulation of heat shock protein 70 in mussels exposed to the two highest concentrations clearly indicated impacts on protein damage.

Dates et versions

hal-00626604 , version 1 (26-09-2011)

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Citer

Valeska Contardo-Jara, Claudia Lorenz, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, et al.. Molecular effects and bioaccumulation of levonorgestrel in the non-target organism Dreissena polymorpha. Environmental Pollution, 2011, 159 (1), pp.38-44. ⟨10.1016/j.envpol.2010.09.028⟩. ⟨hal-00626604⟩
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