Article Dans Une Revue Biochemical Pharmacology Année : 2010

Doxorubicin-induced cell death requires cathepsin B in HeLa cells

Résumé

The cysteine protease cathepsin B acts as a key player in apoptosis. Cathepsin B mediated cell death is induced by various stimuli such as ischemia, bile acids or TNFα. Whether cathepsin B can be influenced by anticancer drugs, however, has not been studied in detail. Here, we describe the modulation of doxorubicin induced cell death by silencing of cathepsin B expression. Previously, it was shown that doxorubicin, in contrast to other drugs, selectively regulates expression and activity of cathepsin B.

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hal-00626231 , version 1 (24-09-2011)

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S. Bien, C. Rimmbach, H. Neumann, J. Niessen, E. Reimer, et al.. Doxorubicin-induced cell death requires cathepsin B in HeLa cells. Biochemical Pharmacology, 2010, 80 (10), pp.1466. ⟨10.1016/j.bcp.2010.07.036⟩. ⟨hal-00626231⟩

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