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Article Dans Une Revue Tetrahedron Année : 2011

Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

Résumé

A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-alkylation and N-benzylation of these hydrazones.
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Dates et versions

hal-00623809 , version 1 (03-02-2021)

Identifiants

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Pierrick Nun, Charlotte Martin, Jean Martinez, Frédéric Lamaty. Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill. Tetrahedron, 2011, 67 (42), pp.8187-8194. ⟨10.1016/j.tet.2011.07.056⟩. ⟨hal-00623809⟩
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