Amino acids as building blocks for the synthesis of substituted 1,2,4-triazoles - Archive ouverte HAL
Article Dans Une Revue Tetrahedron Année : 2011

Amino acids as building blocks for the synthesis of substituted 1,2,4-triazoles

Résumé

We report on the synthesis of 1,2,4-triazoles substituted with 2 or 3 amino acid side chains, using silver benzoate as a key reagent for the cyclization step. A complete study of the optical purity retention during the synthetic process leading to these compounds is described. In addition an improved work-up after the addition-cyclization step was also established leading to better yields and metal-free products.

Domaines

Chimie organique

Dates et versions

hal-00617701 , version 1 (30-08-2011)

Identifiants

Citer

Mathieu Bibian, Jean Martinez, Jean-Alain Fehrentz. Amino acids as building blocks for the synthesis of substituted 1,2,4-triazoles. Tetrahedron, 2011, 67, pp.7042-7049. ⟨10.1016/j.tet.2011.07.011⟩. ⟨hal-00617701⟩
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