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            <title xml:lang="en">Occult B-lymphoproliferative Disorders</title>
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                <title xml:lang="en">Occult B-lymphoproliferative Disorders</title>
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              <p>The term Monoclonal B-lymphocytosis (MBL) was recently introduced to identify individuals with a population of monoclonal B-cells in the absence of other features that are diagnostic of a B-lymphoproliferative disorder. MBL is often identified through hospital investigation of a mild lymphocytosis and approximately 1% of such individuals develop progressive disease requiring treatment per year from diagnosis. However, in population studies using high sensitivity flow cytometry, MBL may be detectable in more than 10% of adults aged over 60 and clinical progression is rare. The majority of MBL cases have features that are characteristic of Chronic Lymphocytic Leukaemia (CLL) but increasing information is becoming available about MBL with the features of other B-lymphoproliferative disorders. In addition to flow cytometry findings, the incidental detection of an occult B-lymphoproliferative disorder is also recognised in a significant proportion of tissue biopsies. In this review the clinical and biological relationship between MBL and B-lymphoproliferative disorders will be discussed with a focus on identifying the differences between low levels of peripheral blood or bone marrow involvement with lymphoma and the monoclonal B-cell populations that are a common occurrence in elderly adults</p>
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