Estimation of the percolation thresholds in ternary lobenzarit disodium–dextran–HPMC hydrophilic matrices tablets: Effects of initial porosity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Pharmaceutical Sciences Année : 2009

Estimation of the percolation thresholds in ternary lobenzarit disodium–dextran–HPMC hydrophilic matrices tablets: Effects of initial porosity

Résumé

The aim of this work is to estimate the excipient percolation threshold for a new combined matrix native dextran (DT), series B110-1-2 (Mw 2×106): HPMC K4M CR: lobenzarit disodium (LBD) system and demonstrate the advantages of this ternary system with respect to previously reported binary dextran:LBD and HPMC:LBD tablets. The formulations studied were prepared with different amounts of excipient (DT:HPMC, 4:1 (wt/wt) for all tablets and relative polymer/drug particle size of 4.17) in the range of 10–70% (wt/wt). Dissolution studies were carried out using the paddle method (100rpm) and one face water uptake measurements were performed using a modified Enslin apparatus. The Higuchi's models as well as the non-linear regression were employed as empiric methods to study the released data. Values of diffusion exponent 0.588
Fichier principal
Vignette du fichier
Castellanos_Gil_24428.pdf (1013.34 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-00610199 , version 1 (16-10-2019)

Identifiants

Citer

Eddy Castellanos Gil, Antonio Iraizoz Colarte, Bernard Bataille, Fabien Brouillet, Isidoro Caraballoc. Estimation of the percolation thresholds in ternary lobenzarit disodium–dextran–HPMC hydrophilic matrices tablets: Effects of initial porosity. European Journal of Pharmaceutical Sciences, 2009, 38 (4), pp.312-319. ⟨10.1016/j.ejps.2009.07.013⟩. ⟨hal-00610199⟩
64 Consultations
47 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More