Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. - Archive ouverte HAL
Article Dans Une Revue Journal of Immunology Année : 2011

Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.

Résumé

It is uncertain whether NK cells modulate T cell memory differentiation. By using a genetic model that allows the selective depletion of NK cells, we show in this study that NK cells shape CD8(+) T cell fate by killing recently activated CD8(+) T cells in an NKG2D- and perforin-dependent manner. In the absence of NK cells, the differentiation of CD8(+) T cells is strongly biased toward a central memory T cell phenotype. Although, on a per-cell basis, memory CD8(+) T cells generated in the presence or the absence of NK cells have similar functional features and recall capabilities, NK cell deletion resulted in a significantly higher number of memory Ag-specific CD8(+) T cells, leading to more effective control of tumors carrying model Ags. The enhanced memory responses induced by the transient deletion of NK cells may provide a rational basis for the design of new vaccination strategies.

Domaines

Immunologie

Dates et versions

hal-00608178 , version 1 (12-07-2011)

Identifiants

Citer

Katrina Soderquest, Thierry Walzer, Biljana Zafirova, Linda S Klavinskis, Bojan Polić, et al.. Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses.. Journal of Immunology, 2011, 186 (6), pp.3304-8. ⟨10.4049/jimmunol.1004122⟩. ⟨hal-00608178⟩
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