Heterogeneous catalysis is of paramount importance in many areas of the chemical and energy industries. Often, however, reactions can be hindered or reaction rates limited by poisoning effects originating from moisture in the air or from the water formed during the organic transformation. Water can be adsorbed and block catalytic sites, leading to their deactivation. This drawback has motivated the design and engineering of catalytic materials with hydrophobic features, such as the hydrophobic outer shell of enzymes, to prevent water-induced catalyst poisoning.