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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2007

Hippocampal place cell assemblies are speed-controlled oscillators.

Caroline Geisler
  • Fonction : Auteur
David Robbe
Michaël Zugaro
Anton Sirota
  • Fonction : Auteur
György Buzsáki
  • Fonction : Auteur
  • PersonId : 902502

Résumé

The phase of spikes of hippocampal pyramidal cells relative to the local field theta oscillation shifts forward ("phase precession") over a full theta cycle as the animal crosses the cell's receptive field ("place field"). The linear relationship between the phase of the spikes and the travel distance within the place field is independent of the animal's running speed. This invariance of the phase-distance relationship is likely to be important for coordinated activity of hippocampal cells and space coding, yet the mechanism responsible for it is not known. Here we show that at faster running speeds place cells are active for fewer theta cycles but oscillate at a higher frequency and emit more spikes per cycle. As a result, the phase shift of spikes from cycle to cycle (i.e., temporal precession slope) is faster, yet spatial-phase precession stays unchanged. Interneurons can also show transient-phase precession and contribute to the formation of coherently precessing assemblies. We hypothesize that the speed-correlated acceleration of place cell assembly oscillation is responsible for the phase-distance invariance of hippocampal place cells.

Dates et versions

hal-00599378 , version 1 (09-06-2011)

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Citer

Caroline Geisler, David Robbe, Michaël Zugaro, Anton Sirota, György Buzsáki. Hippocampal place cell assemblies are speed-controlled oscillators.. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (19), pp.8149-54. ⟨10.1073/pnas.0610121104⟩. ⟨hal-00599378⟩
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